AI-ICE Guided Pulsed Field Ablation of Atrial Fibrillation with Variable Loop Circular Catheter
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ID: 326512
2026
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Abstract
BACKGROUND: Intracardiac echocardiography (ICE) facilitates left atrial (LA) reconstruction during atrial fibrillation (AF) ablation. The artificial intelligence-based CARTOSOUND FAM (AIFAM) module enables automated three-dimensional LA reconstruction without the need for a dedicated pre-ablation mapping catheter. While this workflow has been described previously in radiofrequency ablation, its application and outcome in pulsed field ablation (PFA) remains limited. OBJECTIVE: To evaluate the feasibility, safety, and arrhythmia-free outcomes of a no-pre-mapping AIFAM-guided workflow during PFA using the Variable Loop Circular Catheter (VLCC). METHODS: Patients undergoing PFA AF ablation using VLCC were screen and ones using AIFAM-guided ablation without pre-map were included in analysis. LA shell was created using the AI-based ICE module from the right atrium without the need for LA mapping catheter and was used as the only reference shell for PFA energy delivery. Baseline demographics, AF subtype, comorbidities, procedural details and follow-up outcomes were analyzed. Recurrence was assessed using a 60-day blanking period and Kaplan-Meier survival analysis. RESULTS: A total of 412 patient underwent AF ablation using VLCC during the study period. Among them 210 patients (mean age 68.1 ± 10.2 years; 54.8% male) underwent AIFAM guided ablation without pre-map and were analyzed. AF subtype was paroxysmal in 52% and non-paroxysmal in 48%. Concomitant AF ablation and left atrial appendage occlusion (LAAO) were performed in 76 patients (36%). The mean CHA2DS2-VASc score was 3.4 ± 1.7, and mean LVEF was 56.2 ± 11.1%. All patients underwent pulmonary vein isolation (PVI), with additional PF lesions including posterior wall isolation in 87.5%, superior vena cava ablation in 60.5%. Skin-to-skin procedure time and LA dwell time was 78.8 ± 29.1 min and 47.1 ± 18.8 min for ablation alone and 87.3 ± 22.9 min and 54.6 ± 13.0 min for concomitant AF ablation and LAAO. Acute procedural success was achieved in 100% of cases. One acute non-catheter related vascular complication (0.5%) and no late complications were documented. Among 184 patients with at least one follow-up, freedom from arrhythmia survival after 60-day blanking was 77.7% in paroxysmal AF and 71.8% in non-paroxysmal AF at 270 days. CONCLUSION: AIFAM enables safe and reliable LA reconstruction for successful PFA ablation including concomitant AF ablation and LAAO using VLCC and reduces the need for pre-ablation mapping in select patients undergoing index ablation. This strategy demonstrated high acute success, low complication rates, and favorable arrhythmia freedom in a contemporary cohort.
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| Authors | Fengwei Zou, Sarah Xu, Justin Song, Ariel Gidon, Aung Lin, Nikil Prasad, Nils Guttenplan, Nicola Tarantino, Ronghua Yang, Dhanunjaya Lakkireddy, Vincenzo Mirco La Fazia, Andrea Natale, Sanghamitra Mohanty, Vito Grupposo, Xiaodong Zhang, Luigi Di Biase |
| Journal | EP Europace |
| Year | 2026 |
| DOI |
10.1093/europace/euag212
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| URL | |
| Keywords | Keywords not found |
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