Photo-triggered construction of nitrogen-containing aromatic heterocycles under physiological conditions
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ID: 326286
2026
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Abstract
Abstract Precise spatiotemporal control of molecular function is essential for probing biological systems and developing safer therapeutics. Herein, we review photoinducible intramolecular cyclization reactions developed in-house for generating nitrogen-containing aromatic heterocycles. These photoreactions exploit the unique photoreactivity of o-nitrobenzyl oxime ethers, producing iminyl radicals as key intermediates. Notably, these reactions occur under physiological conditions and in cellulo, thereby expanding the design space for photocontrollable molecules in biological environments.
| Reference Key |
openalex_W7204028509
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|---|---|
| Authors | Hidenori Okamura, Fumi Nagatsugi |
| Journal | phytochemistry letters |
| Year | 2026 |
| DOI |
10.1093/chemle/upag170
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| URL | |
| Keywords | Keywords not found |
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