Neural integrator and orchestrator communities shape spontaneous signaling in the human brain

Clicks: 6
ID: 326284
2026
Free PDF
Article Quality & Performance Metrics
Overall Quality
Not rated
Combines reader engagement with the AI quality analysis. This article has not been analysed, so there is no overall score — reader engagement is measured and shown alongside.
AI Quality Assessment
Not analyzed
Readership in this journal
Emerging

Ranked #43 of 90 articles by views in PNAS nexus

Most read Least read

Bar heights use a square-root scale.

Mint this article as an NFT
Not yet minted

Create a permanent, verifiable on-chain record of this article on the Scimatic Network. The NFT is held in your Journament account, and you can withdraw it to your own wallet at any time.

5 SUSD one-off · no wallet required
Sign in to mint
Abstract
Understanding how intrinsic brain dynamics are organized is critical for explaining human cognition and sensory processing. Theoretical frameworks propose a hierarchical architecture in which some neural systems act as orchestrators, broadcasting information across the brain, whereas others serve as integrators, transforming incoming signals. Here, we quantitatively test whether this orchestration-integration framework is embedded in intrinsic brain activity, that is, in the absence of explicit cognitive/sensorial tasks. We adopt a multivariate fractional modeling framework originally developed in financial mathematics to characterize how volatility propagates across interacting markets, thereby identifying systems that act as orchestrators or integrators. We then test whether this integrator-orchestrator axis is related to human intelligence. To this end, using 7T resting-state functional magnetic resonance imaging data from 173 healthy young adults, we model spontaneous brain fluctuations with a multivariate fractional Ornstein-Uhlenbeck process to derive directional influence indices. Consistent with our predictions, we identified a bipartite organization, stable across modeling choices. At the subcortical level, the anterior thalamus, putamen, and caudate emerged as orchestrating transmitters, whereas the posterior thalamus, globus pallidus, hippocampus, amygdala, and nucleus accumbens acted as integrating receivers. At the cortical level, attentional and sensory networks functioned as orchestrating transmitters, while higher-order cognitive networks served as integrating receivers. These findings provide support for a theoretically grounded integration-orchestration framework, demonstrating that brain signaling is organized along this axis even at rest, relevant for intelligence scores. The proposed fractional framework offers a principled tool to investigate how disruptions of this balance may contribute to brain disorders.
Reference Key
openalex_W7128024266 Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Lorenzo Pini, Ranieri Dugo, Paolo Pigato, M. Corbetta
Journal PNAS nexus
Year 2026
DOI
10.1093/pnasnexus/pgag285
URL
https://doi.org/10.1093/pnasnexus/pgag285
Keywords Keywords not found

Citations

No citations found. To add a citation, contact the admin at info@scimatic.org

Comments

No comments yet. Be the first to comment on this article.