Sex Differences in Coronary Inflammation and Clinical Outcomes Among Patients with Plaque-Positive Non-Obstructive Coronary Artery Disease: A long-term dual-center follow-up study
Clicks: 15
ID: 326277
2026
Article Quality & Performance Metrics
Overall Quality
Not rated
Combines reader engagement with the AI quality analysis. This
article has not been analysed, so there is no overall score —
reader engagement is measured and shown alongside.
Reader Engagement
Emerging Content
4.2
/100
15 views
14 readers
AI Quality Assessment
Not analyzed
Readership in this journal
EmergingRanked #44 of 77 articles by views in european heart journal - quality of care and clinical outcomes
Most read
Least read
Bar heights use a square-root scale.
Mint this article as an NFT
Not yet mintedCreate a permanent, verifiable on-chain record of this article on the Scimatic Network. The NFT is held in your Journament account, and you can withdraw it to your own wallet at any time.
5
SUSD
one-off · no wallet required
Abstract
BACKGROUND: The influence of sex on coronary inflammation in patients with non-obstructive coronary artery disease (CAD) remains unclear. This study aims to determine sex differences in coronary inflammation, quantified by pericoronary fat attenuation index (pFAI) derived from coronary computed tomography angiography (CCTA), and their impact on clinical outcomes among patients with plaque-positive non-obstructive CAD. METHODS: This study retrospectively included 1395 patients with plaque-positive non-obstructive CAD who underwent CCTA (61±10 years, 55.2% males). Major adverse cardiovascular events (MACEs) were defined as cardiac death, non-fatal myocardial infarction, rehospitalization for heart failure or unstable angina, and late revascularization. RESULTS: After a median follow-up of 85 months (interquartile range [IQR]: 72-99), 177 patients experienced MACEs. Male sex was independently associated with elevated coronary inflammation (pFAI > -70.1 HU; OR=1.36, P=0.047). Male patients had a significantly higher cumulative rate of MACE than female patients (P<0.001). Furthermore, patients with coronary inflammation (pFAI > -70.1 HU) exhibited significantly worse long-term outcomes than those without, and consistent findings were observed in both male and female subgroups (all P<0.001). In multivariable Cox regression analysis, pFAI remained independently associated with MACEs in patients with non-obstructive CAD (HR=2.33, P<0.001) and provided incremental prognostic value beyond clinical variables and traditional CCTA metrics (AUC: 0.683-0.781, P<0.001). CONCLUSION: Among patients with plaque-positive non-obstructive CAD, males exhibited worse long-term outcomes than females and showed a stronger association with coronary inflammation. pFAI is independently associated with long-term prognosis and may enhances risk stratification in these patients.
| Reference Key |
openalex_W7203976553
Use this key to autocite in the manuscript while using
SciMatic Manuscript Manager or Thesis Manager
|
|---|---|
| Authors | Bowen Li, Yong Chen, X Yang, Huiyu Chen, Runze Zhu, Jian Wang, Bing Kang, Ximing Wang, Hui Gu |
| Journal | european heart journal - quality of care and clinical outcomes |
| Year | 2026 |
| DOI |
10.1093/ehjqcco/qcag134
|
| URL | |
| Keywords | Keywords not found |
Citations
No citations found. To add a citation, contact the admin at info@scimatic.org
Comments
No comments yet. Be the first to comment on this article.