P1.109. Overexpression of RFC3 Relates to Tumor Development and Poor Outcome of Esophageal Squamous Cell Carcinoma

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ID: 326184
2026
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Ranked #323 of 453 articles by views in diseases of the esophagus : official journal of the international society for diseases of the esophagus

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Abstract
Abstract Topic Esophageal Cancer: Molecular Biology/Pathology Background Replication factor C (activator 1) 3 (RFC3), located on 13q13.2, is reported to be necessary for the elongation of primed DNA templates by DNA polymerase delta and DNA polymerase epsilon. In this study, we tested whether RFC3 acts as a cancer-promoting factor by being overexpressed in esophageal squamous cell carcinoma (ESCC). Methods We analyzed 14 ESCC cell lines and 58 primary tumor samples of ESCC, which were curatively resected in our hospital. Results RFC3 protein was detected in all cell lines and primary tumor samples (39/58 cases; 67.2%). Knockdown of RFC3 using specific siRNA inhibited proliferation in TE-5 and TE-9 of which RFC3 overexpressed strongly. Overexpression of RFC3 protein correlated with lymphatic invasion and worth prognosis. Moreover, multivariate analysis demonstrated that RFC3 was independently associated with worse outcome (p= 0.027, hazard ratio 3.4 (11-15)). Conclusion These findings suggest that RFC3 plays a crucial role in tumor cell proliferation by its overexpression and highlight its usefulness as a prognostic factor and potential therapeutic target in ESCC.
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Authors Hiroyuki Kanazawa, Shuhei Komatsu, Jun Kiuchi, Mahito Miyamae, Shoji Hirajima, Takuma Ohashi, Taisuke Imamura, Keiji Nishibeppu, Ryo Ishida, Satoshi Hamada, Masateru Yamauchi, Kenji Nanishi, Hiroki Shimizu, Tomohiro Arita, Toshiyuki Kosuga, Yusuke Yamamoto, Hirotaka Konishi, Ryo Morimura, Hitoshi Fujiwara, Atsushi Shiozaki
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Journal diseases of the esophagus : official journal of the international society for diseases of the esophagus
Year 2026
DOI
10.1093/dote/doag077.257
URL
https://doi.org/10.1093/dote/doag077.257
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