PD01.07. Surgery Timing After Neoadjuvant Therapy for Esophageal Carcinoma: A Meta-Analysis of 7,544 Patients

Clicks: 24
ID: 326182
2026
Free PDF
Article Quality & Performance Metrics
Overall Quality
Not rated
Combines reader engagement with the AI quality analysis. This article has not been analysed, so there is no overall score — reader engagement is measured and shown alongside.
AI Quality Assessment
Not analyzed
Readership in this journal
Emerging

Ranked #61 of 453 articles by views in diseases of the esophagus : official journal of the international society for diseases of the esophagus

Most read Least read

Bar heights use a square-root scale. Only the 120 most-read articles are drawn; the journal has 453 in total.

Mint this article as an NFT
Not yet minted

Create a permanent, verifiable on-chain record of this article on the Scimatic Network. The NFT is held in your Journament account, and you can withdraw it to your own wallet at any time.

5 SUSD one-off · no wallet required
Sign in to mint
Abstract
Abstract Topic Esophageal Cancer: Adjuvant and Neo-Adjuvant Therapies Background In treating locally advanced esophageal carcinoma, neoadjuvant therapy followed by surgery represents a key approach. However, the timing of surgery following neoadjuvant therapy in esophageal carcinoma remains controversial. Methods We conducted a systematic search of PubMed, EMBASE, Web of Science, and Cochrane Library for studies published up to August 1, 2024. Studies that compared delayed versus early surgery for locally advanced esophageal carcinoma following neoadjuvant therapy were included. A fixed-effects or random-effects model was used based on heterogeneity. Results A total of 21 studies involving 7,544 patients with esophageal carcinoma were analyzed. Delayed surgery was associated with a higher incidence of anastomotic leakage (OR = 1.39, P=0.007) and lower R0 resection rates (OR = 0.59, P < 0.001). However, there was no significant difference in pulmonary complications, perioperative mortality, or pathological complete response rates between the early and delayed surgery groups. Long-term overall survival was poorer in the delayed surgery group (HR = 1.12, P=0.05), although disease-free survival showed no significant difference. Additionally, There were no significant differences in the incidence of chylothorax, RLN injury, or postoperative cardiovascular complications between the groups. Conclusion While delayed surgery after neoadjuvant therapy in esophageal carcinoma patients may be associated with a higher risk of anastomotic leaks and a lower rate of R0 resection, its impact on long-term survival remains an area of ongoing investigation. Future randomized controlled trials are needed to further clarify the optimal timing of surgery and identify potential benefits of delaying surgery in certain patients.
Reference Key
openalex_W7204002402 Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Jianfeng Zhou, Pinhao Fang, Yong Yuan, Zewen Wang
Are you one of these authors? Claim your profile
Journal diseases of the esophagus : official journal of the international society for diseases of the esophagus
Year 2026
DOI
10.1093/dote/doag077.077
URL
https://doi.org/10.1093/dote/doag077.077
Keywords Keywords not found

Citations

No citations found. To add a citation, contact the admin at info@scimatic.org

Comments

No comments yet. Be the first to comment on this article.