PD06.03. Frequency of Gastroesophageal Reflux Disease Depending on the Presence of H.pylori Infection

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ID: 326126
2026
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Abstract
Abstract Topic Benign Disease: Gastro-Esophageal Reflux and Hiatal Hernia Background Gastroesophageal reflux disease (GERD) affects 14% of adults worldwide, but the impact of concomitant H.pylori infection on the development of its symptoms has been poorly studied. Altered hydrochloric acid secretion due to H.pylori infection potentially influences the development of gastroesophageal reflux. Therefore, studying the frequency of GERD symptoms in infected patients is a pressing issue. Methods As part of the epidemiological study, 5107 people were examined (men - 2270 (44.4%), women - 2837 (55.6%). The age of the subjects ranged from 18 to 80 years, the average age was 46.10 ± 15.18 years (median age was 45 (34; 59) years). All respondents underwent 13C-urea breath test (13C-UBT). The results of 13C-UBT, obtained using infrared spectrometry, were assessed by quantitative characteristics: negative (DOB less than 4‰), positive (DOB more than 4‰). The criterion for GERD was the presence of heartburn and / or regurgitation 1 time per week or more often. Results Among 5107 subjects, H.pylori infection was detected in 2016 people (39.5%). The frequency of heartburn and/or regurgitation once a week or more among respondents in both groups was comparable and amounted to 19.2% (387 of 2016) in H.pylori-positive respondents and 17.6% (545 of 3091) in H.pylori-negative respondents (p=0.157). Conclusion When comparing the frequency of GERD symptoms with the status of H.pylori infection, it was found that the presence or absence of H.pylori infection did not affect the frequency of GERD symptoms.
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Authors Margarita Chebotareva, Karine Nikolskaya, Dmitri Bordin, Valeria Lomova
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Journal diseases of the esophagus : official journal of the international society for diseases of the esophagus
Year 2026
DOI
10.1093/dote/doag077.115
URL
https://doi.org/10.1093/dote/doag077.115
Keywords Keywords not found

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