P1.129. Predictive Value of Baseline Bioelectrical Impedance Analysis(BIA) for Chemoradiotherapy Completion in Locally Advanced Esophageal Cancer: Implications for Prehabilitation

Clicks: 22
ID: 326091
2026
Free PDF
Article Quality & Performance Metrics
Overall Quality
Not rated
Combines reader engagement with the AI quality analysis. This article has not been analysed, so there is no overall score — reader engagement is measured and shown alongside.
AI Quality Assessment
Not analyzed
Readership in this journal
Steady

Ranked #105 of 453 articles by views in diseases of the esophagus : official journal of the international society for diseases of the esophagus

Most read Least read

Bar heights use a square-root scale. Only the 120 most-read articles are drawn; the journal has 453 in total.

Mint this article as an NFT
Not yet minted

Create a permanent, verifiable on-chain record of this article on the Scimatic Network. The NFT is held in your Journament account, and you can withdraw it to your own wallet at any time.

5 SUSD one-off · no wallet required
Sign in to mint
Abstract
Abstract Topic Esophageal Cancer: Oncology/Radiation Therapy Background Locally advanced esophageal cancer requires toxic chemoradiotherapy, yet no established pretreatment body composition thresholds exist to predict completion. Traditional assessment relies on subjective performance status, often overlooking occult sarcopenia. This study evaluates BIA markers against BMI to define objective cut-offs for guiding targeted prehabilitation and optimizing therapeutic resilience. Methods A retrospective cohort study analyzed patients with locally advanced esophageal cancer undergoing definitive or neoadjuvant CCRT at a provincial tertiary center in Thailand from December 2023 to October 2025. Baseline body composition was assessed using direct segmental multi-frequency bioelectrical impedance analysis immediately post-diagnosis. Patients were categorized into "Completion CCRT" (n=30) and "Non-completion CCRT" (n=11; withdrawal, loss to follow-up, early mortality) treatment groups. We compared baseline BMI, PhA, SMI, and other body composition parameters between groups using independent t-tests and Mann-Whitney U tests to identify predictors of treatment resilience. Results Forty-one patients (mean age 60.3±10.3; 95.1% male; 97.6% SCC) were included. The CCRT completion rate was 73.2% (30/41). While the Non-completion CCRT group had significantly lower weight (39.7 vs 47.5 kg, p=0.002) and BMI (15.0 vs 17.4 kg/m2, p=0.009), BIA revealed critical underlying deficits. The Non-completion group demonstrated significantly depleted Skeletal Muscle Index (5.43 vs 6.22 kg/m2, p=0.006), Fat Mass (4.4 vs 7.3 kg, p=0.033), and Basal Metabolic Rate (1132 vs 1246 kcal, p=0.003). Although Phase Angle was lower in the Non-completion group (4.68° vs 5.29°), it did not reach statistical significance (p=0.274). These findings characterize a state of severe cachexia driving treatment failure. Conclusion Baseline BIA parameters effectively identify high-risk phenotypes driving CCRT failure. While validation in larger cohorts is warranted, future research should focus on monitoring BIA dynamics following nutritional interventions. Ultimately, this study serves as a pivotal foundation for implementing targeted prehabilitation, aiming to optimize physiological resilience and ensure treatment completion in locally advanced esophageal cancer.
Reference Key
openalex_W7203974974 Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Panpanit Sukwarodwat, Somjai Nokdee, Wilawan Tapalad
Are you one of these authors? Claim your profile
Journal diseases of the esophagus : official journal of the international society for diseases of the esophagus
Year 2026
DOI
10.1093/dote/doag077.277
URL
https://doi.org/10.1093/dote/doag077.277
Keywords Keywords not found

Citations

No citations found. To add a citation, contact the admin at info@scimatic.org

Comments

No comments yet. Be the first to comment on this article.