PD02.03. Proximal Resection Margin and Survival in Esophageal Adenocarcinoma Surgery Following Neoadjuvant Therapy

Clicks: 15
ID: 326072
2026
Free PDF
Article Quality & Performance Metrics
Overall Quality
Not rated
Combines reader engagement with the AI quality analysis. This article has not been analysed, so there is no overall score — reader engagement is measured and shown alongside.
AI Quality Assessment
Not analyzed
Readership in this journal
Steady

Ranked #437 of 453 articles by views in diseases of the esophagus : official journal of the international society for diseases of the esophagus

Most read Least read

Bar heights use a square-root scale. Only the 120 most-read articles are drawn; the journal has 453 in total.

Mint this article as an NFT
Not yet minted

Create a permanent, verifiable on-chain record of this article on the Scimatic Network. The NFT is held in your Journament account, and you can withdraw it to your own wallet at any time.

5 SUSD one-off · no wallet required
Sign in to mint
Abstract
Abstract Topic Esophageal Cancer: Surgical Treatment of Esophageal Cancer Background Achieving an adequate proximal resection margin is considered essential for oncologic control in esophageal adenocarcinoma. However, the prognostic significance of margin length following neoadjuvant therapy remains uncertain, particularly in patients who don't complete adjuvant chemotherapy. This study evaluates the clinical impact of proximal margin distance and adherence to national guidelines. Methods This retrospective single-center study included 221 patients treated at a high-volume tertiary referral center. All patients received neoadjuvant therapy before esophagectomy for esophageal adenocarcinoma between 2019 and 2021. The year of the last follow-up was 2023. Two experienced upper gastrointestinal pathologists independently evaluated the oral tumor-free resection margins after formalin fixation. Adherence to the national guideline-recommended proximal margin of ≥38 mm was assessed. Results The mean proximal resection margin was 31.3 ± 17.4 mm, and 30.2% of patients achieved the national guideline-recommended margin of ≥38 mm. The mean margin was significantly lower than the recommended 38 mm (one-sample t-test, p < 0.001). Proximal margin distance, analyzed both as a continuous variable and as a dichotomous variable at clinically relevant and data-driven cutoffs, was not independently associated with overall or recurrence-free survival. However, in an exploratory subgroup analysis of patients who did not complete adjuvant chemotherapy, a non-significant trend toward inferior recurrence-free survival was observed for margins ≤16 mm (p = 0.078). Conclusion The achieved proximal resection margin was significantly lower than the national guideline-recommended threshold (p < 0.001). However, proximal margin length was not independently associated with overall or recurrence-free survival. Larger, adequately powered studies with longer follow-up are warranted to clarify the potential prognostic relevance of proximal margin distance in patients receiving neoadjuvant therapy.
Reference Key
openalex_W7203988820 Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Laser Arif Bazancir, Andreas Weise Mucha, Thomas B. Piper, Trygve Ulvund Solstad, Gustav Holm Schæbel, Mette K. Nedergaard, Rajendra Singh Garbyal, Michael Patrick Achiam
Are you one of these authors? Claim your profile
Journal diseases of the esophagus : official journal of the international society for diseases of the esophagus
Year 2026
DOI
10.1093/dote/doag077.081
URL
https://doi.org/10.1093/dote/doag077.081
Keywords Keywords not found

Citations

No citations found. To add a citation, contact the admin at info@scimatic.org

Comments

No comments yet. Be the first to comment on this article.