P1.107. Macrophage Infiltration and FoxP3 Density Predict Treatment Response and Survival in Esophageal Cancer Patients

Clicks: 18
ID: 326033
2026
Free PDF
Article Quality & Performance Metrics
Overall Quality
Not rated
Combines reader engagement with the AI quality analysis. This article has not been analysed, so there is no overall score — reader engagement is measured and shown alongside.
AI Quality Assessment
Not analyzed
Readership in this journal
Steady

Ranked #301 of 453 articles by views in diseases of the esophagus : official journal of the international society for diseases of the esophagus

Most read Least read

Bar heights use a square-root scale. Only the 120 most-read articles are drawn; the journal has 453 in total.

Mint this article as an NFT
Not yet minted

Create a permanent, verifiable on-chain record of this article on the Scimatic Network. The NFT is held in your Journament account, and you can withdraw it to your own wallet at any time.

5 SUSD one-off · no wallet required
Sign in to mint
Abstract
Abstract Topic Esophageal Cancer: Molecular Biology/Pathology Background The tumor microenvironment (TME) holds an important role in the biological behaviour of the esophageal cancer, influenced by neoadjuvant treatment (NAT). However, its correlation to patient outcomes remains poorly defined. The aim of this study was to assess the prognostic value of TME in terms of long-term recurrence and survival. Methods All eligible patients with esophageal adenocarcinoma (EAC) and squamous cell carcinoma (SCC), treated with curative intent including surgery between 01.2009 and 12.2021, were retrospectively analyzed. Immunohistochemical analysis of pre-treatment biopsies and surgical specimens, was performed for biomarkers CD3, CD8, CD68, CD163, Treg/FoxP3 and PD-L1 (combined positive score, CPS). Histologic slides were scanned at high resolution (x400), and the above biomarkers were eye-counted as mean number/high power field. Pathological response to NAT was assessed with the Mandard tumor regression grade (TRG). The chi2 and Fisher tests were used to compare categorical, and the student’s t test continuous variables. Overall survival (OS) and disease-free survival (DFS) were analyzed using Cox simple and multiple regression. Results Overall, 64 patients were included (51 EAC, 13 SCC) in the present study; 81% of patients were male, with a median age of 64 years (IQR 57-69), and a median follow-up of 48 months. Although baseline TME composition was comparable in all patients, poor pathological responders (TRG 3-5) showed higher macrophage infiltration after NAT compared to good responders (TRG 1-2) (Mean total macrophages [CD68+] 63.6 poor vs 44.3 good responders, p = 0.002, mean M2-like [CD163+] 50.3 poor vs 38.3 good responders, p = 0.038). In multivariable analysis, Treg/FoxP3 expression (HR 0.95, 95% CI 0.90–1.00, p = 0.041) and pathological nodal status (HR 2.37, 95% CI 1.58–3.54, p < 0.001) remained independent predictors of DFS, but not OS. Within the EAC subgroup, FOXP3 expression was associated with more favourable OS (adjHR 0.93, 95% CI0.88–0.98, p = 0.008) and DFS (adjHR 0.95, 95% CI 0.90–1.00, p = 0.049). Conclusion The present study indicates increased macrophage concentration (total and M2-like phenotype) to be related to poor response to NAT. In addition, increased numbers of Treg/FOXP3 lymphocytes were associated with a more favourable overall and disease-free patient survival especially within the adenocarcinoma histology. Targeted agents with inhibitory action towards macrophages and expansive action for Treg/FOXP3 lymphocytes might have therapeutic potential for esophageal cancer patients.
Reference Key
openalex_W7204012107 Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Hugo Teixeira Farinha, François Fasquelle, Raphaël Marangon, Christine Sempoux, Markus Schäfer, Fulvia Serra, Styliani Mantziari
Are you one of these authors? Claim your profile
Journal diseases of the esophagus : official journal of the international society for diseases of the esophagus
Year 2026
DOI
10.1093/dote/doag077.255
URL
https://academic.oup.com/dote/article-pdf/39/Supplement_1/doag077.255/70761300/doag077.255.pdf
Keywords Keywords not found

Citations

No citations found. To add a citation, contact the admin at info@scimatic.org

Comments

No comments yet. Be the first to comment on this article.