P1.207. Reduced Risk of Postoperative Chyle Leak in Patients With Obesity After Esophagectomy for Esophageal Cancer - a Nationwide Cohort Study

Clicks: 20
ID: 326015
2026
Free PDF
Article Quality & Performance Metrics
Overall Quality
Not rated
Combines reader engagement with the AI quality analysis. This article has not been analysed, so there is no overall score — reader engagement is measured and shown alongside.
AI Quality Assessment
Not analyzed
Readership in this journal
Steady

Ranked #198 of 453 articles by views in diseases of the esophagus : official journal of the international society for diseases of the esophagus

Most read Least read

Bar heights use a square-root scale. Only the 120 most-read articles are drawn; the journal has 453 in total.

Mint this article as an NFT
Not yet minted

Create a permanent, verifiable on-chain record of this article on the Scimatic Network. The NFT is held in your Journament account, and you can withdraw it to your own wallet at any time.

5 SUSD one-off · no wallet required
Sign in to mint
Abstract
Abstract Topic Esophageal Cancer: Surgical Treatment of Esophageal Cancer – early outcomes and complications Background Esophagectomy is a cornerstone in the treatment of esophageal cancer. Although postoperative chyle leak (PCL) is uncommon, it is clinically important due to its associated morbidity and often challenging management. This study aimed to investigate risk factors for PCL and associations with survival in a nationwide cohort. Methods All patients with esophageal cancer, registered in the Swedish National Registry for Esophageal and Gastric Cancer (NREV) between 2006 and 2025, were included. The study represents an updated analysis of PCL in NREV, including an expanded cohort with extended follow-up. Directed acyclic graphs (DAGs) were used to identify confounders and guide covariate selection. Missing data for key variables were handled with multiple imputation. Variables associated with PCL were analyzed with adjusted multivariable logistic regression, and estimates were pooled according to Rubin’s rules. Overall and adjusted survival were assessed with the Kaplan–Meier method and Cox proportional hazards regression. Results A total of 3,182 patients with esophageal cancer undergoing esophagectomy were included. PCL occurred in 97 patients (3.0%), of whom 57 (58.8%) required interventional radiology or surgical management. Patients with PCL had a longer median hospital stay compared with those without PCL (23 vs. 14 days, p <0.001). In multivariable logistic regression, overweight patients (BMI >25) and patients with obesity (BMI >30) had a significantly lower risk of PCL (OR 0.60 [95% CI 0.37–0.98]; OR 0.43 [95% CI 0.21–0.88], respectively). Neoadjuvant chemo- or chemoradiotherapy was associated with an increased risk of PCL (OR 2.92 [95% CI 1.47–5.81]). There was no significant association between PCL and overall survival. Conclusion PCL is a clinically important complication after esophagectomy, prolonging hospitalization and often requiring reintervention. Overweight patients and patients with obesity appear to have a lower risk of PCL, possibly due to a reduced risk of accidental thoracic duct injury in an adipose mediastinum. Neoadjuvant treatment was associated with an increased risk of PCL. In contemporary clinical practice, PCL does not appear to compromise long-term survival. Further studies on preventive strategies and perioperative management are warranted.
Reference Key
openalex_W7203997561 Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Ellinor Eriksson, Jakob Hedberg, Gustav Linder
Are you one of these authors? Claim your profile
Journal diseases of the esophagus : official journal of the international society for diseases of the esophagus
Year 2026
DOI
10.1093/dote/doag077.355
URL
https://doi.org/10.1093/dote/doag077.355
Keywords Keywords not found

Citations

No citations found. To add a citation, contact the admin at info@scimatic.org

Comments

No comments yet. Be the first to comment on this article.