P1.057. Early Recurrence After Neoadjuvant Therapy and Esophagectomy for Locally Advanced ESCC
Clicks: 7
ID: 326012
2026
Article Quality & Performance Metrics
Overall Quality
Not rated
Combines reader engagement with the AI quality analysis. This
article has not been analysed, so there is no overall score —
reader engagement is measured and shown alongside.
Reader Engagement
Emerging Content
1.8
/100
7 views
6 readers
AI Quality Assessment
Not analyzed
Readership in this journal
EmergingRanked #6 of 453 articles by views in diseases of the esophagus : official journal of the international society for diseases of the esophagus
Most read
Least read
Bar heights use a square-root scale. Only the 120 most-read articles are drawn; the journal has 453 in total.
Mint this article as an NFT
Not yet mintedCreate a permanent, verifiable on-chain record of this article on the Scimatic Network. The NFT is held in your Journament account, and you can withdraw it to your own wallet at any time.
5
SUSD
one-off · no wallet required
Abstract
Abstract Topic Esophageal Cancer: Adjuvant and Neo-Adjuvant Therapies Background Despite improved interventions with radical esophagectomy accompanied by perioperative systematic therapy, recurrence remains frequent in locally advanced esophageal squamous cell carcinoma (ESCC). A clinically important subset experiences early recurrence (ER), which is often followed by rapid deterioration and limited opportunities for effective salvage therapy. Identifying patients at high risk of ER and understanding the dominant failure patterns may inform postoperative surveillance intensity and risk-adapted adjuvant strategies. We aimed to determine clinicopathologic predictors of ER and to characterize recurrence patterns after curative resection. Methods We retrospectively analyzed a prospectively maintained cohort of patients with locally advanced ESCC treated with neoadjuvant chemotherapy (nCT) or chemoradiotherapy (nCRT) followed by curative esophagectomy. ER was defined as any recurrence within 12 months after surgery, non-ER comprised patients recurring later or remaining recurrence-free. Clinicopathologic characteristics were compared between groups. Factors associated with ER were ssessed using Cox regression, and recurrence patterns were compared using categorical models. Results Among 517 patients, 238 (46.0%) developed recurrence, and 126/238 (52.9%) occurred within 12 months. Univariable predictors of ER included comorbidity (HR=1.356; p=0.049), pathologic regression (HR=0.506; p=0.006 for complete; HR=0.572; p=0.001 for major), invasion depth (HR=0.543; p=0.001), lymph-node invasion (HR=2.380; p<0.001), and tumor deposits (HR=2.368; p<0.001). Female sex showed borderline significance (HR=0.584; p=0.053). Multivariable analysis identified major pathologic regression (HR=0.741; p=0.089), lymph-node invasion (HR=2.000; p<0.001), and tumor deposits (HR=1.656; p=0.021) as independent predictors for ER. ER was more often distant than locoregional (RR=1.70; p=0.07). Non-ER patients had markedly better overall survival (HR=0.102; p<0.001), most evident within 24 months. Conclusion Early recurrence within 12 months after neoadjuvant therapy and curative esophagectomy is common in locally advanced ESCC and is independently associated with treatment response, lymph-node involvement, and tumor deposits. ER shows a tendency toward distant failure and confers substantially worse early postoperative survival. supporting intensified surveillance and risk-adapted postoperative strategies.
| Reference Key |
openalex_W7203974729
Use this key to autocite in the manuscript while using
SciMatic Manuscript Manager or Thesis Manager
|
|---|---|
| Authors | Su Feng, Subinuer Maimaiti, Xu Huang, Jun Yin, Yaxing Shen |
| Journal | diseases of the esophagus : official journal of the international society for diseases of the esophagus |
| Year | 2026 |
| DOI |
10.1093/dote/doag077.205
|
| URL | |
| Keywords | Keywords not found |
Citations
No citations found. To add a citation, contact the admin at info@scimatic.org
Comments
No comments yet. Be the first to comment on this article.