OA08.5. Incidence of Lymph Node Metastases in pT1 Chemo- and Radiotherapy Naïve Esophageal and Gastric Cancer in the Nordic Countries

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ID: 325973
2026
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Abstract
Abstract Topic Esophageal Cancer: Barrett‘s Esophagus: High-Grade Dysplasia and Early Invasive Cancer Background Although endoscopic resection is reported to be safe for early stage esophagogastric cancer, uncertainty remains regarding oncological efficacy, particularly for submucosal lesions. The aim of this study was to assess the frequency of lymph node metastasis (LNM) and survival in patients operated for chemo- and radiotherapy naïve pT1 esophagogastric cancer. Methods Patients who underwent surgical resection for esophageal or gastric pT1 adenocarcinoma or squamous cell carcinoma without neoadjuvant oncologic treatment were included. Data were retrospectively extracted from registries in Denmark (2013-2021), Norway (2007-2024), Sweden (2012-2022), and Finland (2000-2016). The primary outcome was the frequency of LNM in patients operated for pT1 esophagogastric cancer. Secondary outcomes included: 5-year overall survival, number of lymph nodes harvested, and risk factors associated with LNM and mortality. Results 1647 patients with pT1 tumors were identified, of whom 949 (58%) did not receive neoadjuvant treatment. Of these 949 patients, esophagectomy had been performed in 413 (43%) and gastric resection in 536 (56%). 146 (15%) patients had LNM identified in the resected specimens: 19 (6%) with pT1a tumors and 127 (21%) with pT1b tumors. The median follow-up was 47 months (Interquartile range: 24-81) and 5-year overall survival was 81% for patients with pT1a tumors and 65% for those with pT1b tumors. Among patients with pT1b, the overall survival was 69% without LNM and 51% with LNM. Depth of tumor invasion was associated with risk of LNM. Conclusion A high proportion of patients had LNM after resection for chemo- and radiotherapy naïve pT1 esophagogastric cancer.
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Authors David Edholm, Joonas H. Kauppila, Michael Patrick Achiam, Oliver Nørholm Kempf, Tobias Hauge, Mats Lindblad, Tom Mala
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Journal diseases of the esophagus : official journal of the international society for diseases of the esophagus
Year 2026
DOI
10.1093/dote/doag077.057
URL
https://doi.org/10.1093/dote/doag077.057
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