P1.127. A Case of Unresectable Advanced Esophageal Cancer Successfully Treated With ICI Regimen and RIC

Clicks: 24
ID: 325919
2026
Free PDF
Article Quality & Performance Metrics
Overall Quality
Not rated
Combines reader engagement with the AI quality analysis. This article has not been analysed, so there is no overall score — reader engagement is measured and shown alongside.
AI Quality Assessment
Not analyzed
Readership in this journal
Steady

Ranked #52 of 453 articles by views in diseases of the esophagus : official journal of the international society for diseases of the esophagus

Most read Least read

Bar heights use a square-root scale. Only the 120 most-read articles are drawn; the journal has 453 in total.

Mint this article as an NFT
Not yet minted

Create a permanent, verifiable on-chain record of this article on the Scimatic Network. The NFT is held in your Journament account, and you can withdraw it to your own wallet at any time.

5 SUSD one-off · no wallet required
Sign in to mint
Abstract
Abstract Topic Esophageal Cancer: Oncology/Radiation Therapy Background Immune checkpoint inhibitors are used for unresectable, advanced, and recurrent esophageal cancer. Currently, the Japan Esophageal Society recommends a 5Fu/CDDP + ICI regimen as first-line treatment. Here, we present a suggestive case of a patient with dysphasia score 4 who had extensive infiltration of the aorta, trachea, and bronchi, in whom an ICI regimen and endoscopic treatment were effective. Methods Case presentation: A woman in her 60s visited our hospital complaining of dysphagia. Upper endoscopy revealed severe circumferential stenosis, primarily in the Mt region. Further examination revealed advanced esophageal cancer with complete stenosis and lymph node metastasis in the cervical, mediastinal, and abdominal regions. Cytology was attempted, but was not performed due to the patient's tendency to bleed. After admission, a PICC was inserted and treatment with 5Fu, cisplatin, and nivolumab was initiated. At the end of the first course, fluoroscopy confirmed contrast passage, and oral semi-digested nutrition was initiated. At the end of the second course, circumferential scarring resulted in complete stenosis, and fluid intake was again impossible. However, endoscopic biopsy revealed no malignant cells. Furthermore, pituitary dysfunction due to irAE was noted, and oral steroids were initiated. Later, irAE-associated nephritis developed, and steroid pulse therapy was initiated. PET-CT and endoscopy confirmed complete response. Results Only two courses of 5Fu + cisplatin + nivolumab therapy were administered, but no further chemotherapy was administered. One year after the initial treatment, endoscopic RIC, radial incision and cutting, was performed. This allowed the patient to eat a normal diet for the first time in a year. One year and three months have now passed, and the patient is still experiencing a complete response. In cases of unresectable disease with a large tumor burden accompanied by complete stenosis and tracheal stenosis, cytotoxic drugs and ICI are the treatment of choice in clinical practice. In this case, the tumor volume was such that no existing normal esophageal tissue could be identified, but RIC was effective in achieving complete scar stenosis after a marked response. Furthermore, with the ICI regimen, we have seen cases where no recurrence has occurred even after treatment completion. Conclusion It may be useful to try RIC in such life-threatening cases in the future if it proves effective, but it is preferable to perform it at a high-volume center with a large amount of experience. We present here examples of multidisciplinary treatment, including the selection of an ICI regimen, treatment for irAEs by multiple medical departments, and RIC, in the treatment of esophageal cancer with a large amount of unresectable advanced tumor, as these are highly suggestive.
Reference Key
openalex_W7203976694 Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Yoshihiro Tanaka, Noya Masuda, Jyun Takada, Yuta Sato, Yuji Hatanaka, Itaru Yasufuku, Masahiro Fukada, Asai Ryuichi, Tajima Jesse Yu, Nobuhisa Matsuhashi, Masahito Shimizu
Are you one of these authors? Claim your profile
Journal diseases of the esophagus : official journal of the international society for diseases of the esophagus
Year 2026
DOI
10.1093/dote/doag077.275
URL
https://academic.oup.com/dote/article-pdf/39/Supplement_1/doag077.275/70760753/doag077.275.pdf
Keywords Keywords not found

Citations

No citations found. To add a citation, contact the admin at info@scimatic.org

Comments

No comments yet. Be the first to comment on this article.