P1.229. Prognostic Value of Tumor Length in Clinical T1–2N0M0 Esophageal Squamous Cell Carcinoma

Clicks: 18
ID: 325911
2026
Free PDF
Article Quality & Performance Metrics
Overall Quality
Not rated
Combines reader engagement with the AI quality analysis. This article has not been analysed, so there is no overall score — reader engagement is measured and shown alongside.
AI Quality Assessment
Not analyzed
Readership in this journal
Steady

Ranked #293 of 453 articles by views in diseases of the esophagus : official journal of the international society for diseases of the esophagus

Most read Least read

Bar heights use a square-root scale. Only the 120 most-read articles are drawn; the journal has 453 in total.

Mint this article as an NFT
Not yet minted

Create a permanent, verifiable on-chain record of this article on the Scimatic Network. The NFT is held in your Journament account, and you can withdraw it to your own wallet at any time.

5 SUSD one-off · no wallet required
Sign in to mint
Abstract
Abstract Topic Esophageal Cancer: Surgical Treatment of Esophageal Cancer – long term outcomes Background The TNM staging system for esophageal cancer defines the T stage by depth of invasion rather than tumor size. However, prognosis may vary within the same T stage. This study aimed to evaluate the prognostic value of tumor length in clinical T1–2N0M0 esophageal squamous cell carcinoma (ESCC). Methods This retrospective single-center study included 923 patients who underwent upfront surgery for cT1–2N0M0 ESCC between 2006 and 2023. The prognostic impact of tumor length was analyzed using Kaplan–Meier curves, log-rank tests, and Cox regression models. Since current guidelines define ≥30 mm as a high-risk threshold, survival outcomes were compared using both the 30 mm cutoff and a cohort-derived cutoff identified by a maximally selected log-rank test. Results The maximally selected log-rank test identified 40 mm as the optimal cutoff for tumor length. Kaplan–Meier analysis demonstrated a clear separation of curves: patients with tumor length ≥40 mm had significantly worse survival (5-year RFS 62% vs. 78%; 5-year OS 68% vs. 84%). Univariable Cox regression demonstrated that tumor length ≥40 mm was significantly associated with worse recurrence-free survival (HR 1.49, p=0.001) and overall survival (HR 1.57, p<0.001). However, in multivariable Cox regression, the prognostic effect of tumor length did not remain significant (p=0.076), being largely explained by pT and pN stage. Independent predictors included age, pT, and pN stage. Conclusion Tumor length ≥40 mm is associated with adverse survival in univariable analysis but does not act as an independent prognostic factor after adjustment for stage. Tumor length reflects tumor burden and should be considered a supportive marker rather than a standalone risk factor in early-stage ESCC.
Reference Key
openalex_W7203986158 Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors YoHan Bae, JiYong Kim, Hyeong Ryul Kim, Yong‐Hee Kim, Jae Kwang Yun
Are you one of these authors? Claim your profile
Journal diseases of the esophagus : official journal of the international society for diseases of the esophagus
Year 2026
DOI
10.1093/dote/doag077.377
URL
https://academic.oup.com/dote/article-pdf/39/Supplement_1/doag077.377/70761263/doag077.377.pdf
Keywords Keywords not found

Citations

No citations found. To add a citation, contact the admin at info@scimatic.org

Comments

No comments yet. Be the first to comment on this article.