PD05.02. Biological Age Reflects Physical Condition and Predicts Postoperative Complications Beyond Chronological Age in Patients With Esophageal Squamous Cell Carcinoma

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ID: 325770
2026
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Ranked #154 of 453 articles by views in diseases of the esophagus : official journal of the international society for diseases of the esophagus

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Abstract
Abstract Topic Esophageal Cancer: Surgical Treatment of Esophageal Cancer – early outcomes and complications Background Chronological age is an important indicator of the physical condition of patients; however, it may not fully capture their physiological status. Recently, biological age has gained attention as a more accurate predictor of physical condition. This study aimed to investigate the association between biological age and postoperative outcomes in patients with esophageal squamous cell carcinoma (ESCC). Methods In this retrospective cohort study conducted between September 2013 and December 2023, 345 patients with ESCC who underwent minimally invasive esophagectomy at Kobe University Hospital were included. Biological age was estimated using Levine et al.’s model based on routine blood tests. Patients were stratified by biological age: ≥75 years and <75 years. Results Patients with a biological age ≥75 years were more likely to be male (p = 0.012) and had lower serum albumin levels (p = 0.0003) and higher creatinine levels (p = 0.0009) than those with a biological age <75 years. Patients with a biological age ≥75 years had higher rates of pulmonary complications (p = 0.032) and anastomotic leakage (p = 0.038). In contrast, no significant differences were observed between the chronological age ≥75 and <75 groups. For long-term outcomes, no significant differences in overall survival were observed between the biological age ≥75 and <75 groups, regardless of disease stage. Among patients with advanced ESCC, 93% of those with a chronological age <75 years but a biological age ≥75 years received preoperative chemotherapy. Conversely, only 80% of patients with a chronological age ≥75 years but a biological age <75 years, who were in better general condition, received preoperative chemotherapy. Conclusion Biological age is associated with postoperative complications. The proportion of patients receiving preoperative chemotherapy was associated with their survival outcomes. Assessing physical condition using biological age may help determine patients’ eligibility for preoperative chemotherapy.
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Authors Yasufumi Koterazawa, Hironobu Goto, Tomoaki Aoki, Yutaka Sugita, Taro Ikeda, Hitoshi Harada, Yasunori Otowa, Naoki Urakawa, Hiroshi Hasegawa, Shingo Kanaji, Takeru Matsuda, Yoshihiro Kakeji
Journal diseases of the esophagus : official journal of the international society for diseases of the esophagus
Year 2026
DOI
10.1093/dote/doag077.105
URL
https://doi.org/10.1093/dote/doag077.105
Keywords Keywords not found

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