PD06.08. Gastroesophageal Reflux Disease in Patients With Autoimmune Gastritis

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ID: 325755
2026
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Ranked #159 of 453 articles by views in diseases of the esophagus : official journal of the international society for diseases of the esophagus

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Abstract
Abstract Topic Benign Disease: Gastro-Esophageal Reflux and Hiatal Hernia Background There is no specific symptoms of autoimmune gastritis, but these patients often present with symptoms of GERD. The Lyon Consensus recommends using AET greater than 6 as the main criterion for pathological reflux. Daily pH impedance monitoring is an ideal method for confirming gastroesophageal reflux, but this criterion is questionable in the absence of gastric acid production. The aim of our study was to evaluate gastroesophageal refluxes in symptomatic patients with autoimmune gastritis. Methods 33 patients with autoimmune gastritis who had symptoms of GERD were included in this study: 29 females and 4 males at the age from 36 to 75 y.o. Seven patients had heartburn, 14 – cough, 7 – burn and pain in throat, 4 - hoarsness, 5 – acidity in a mouth. All patients were underwent upper endoscopy after 2 weeks off-PPI, esophageal manometry and 24h ph impedance monitoring. We used special pH impedance probes to localize pH electrodes in a stomach, 5 cm above LES and 1 cm above upper esophageal sphincter. Results According to endoscopy we didn’t found erosive esophagitis. According to pH monitoring there we didn’t evaluate acidity in a stomach, therefore the acid exposure time was less than 4: 0,09%±0,21. All patients were divided into 3 groups: I group - the total number of refluxes was more than 80, II group – the total number of refluxes from 40 to 79, III group – the total number of refluxes was less than 39. Almost all refluxes were nonacid. Two patients included into group I: one person had 144 refluxes; another one had 102 refluxes and complaint. The group II consisted of 11 patients with mean total number of refluxes: 35,42±19,8, 3 of them had esophageal hypersensitivity. The group III were presented by 20 patients with mean total number of refluxes 23,9 ±9,2, 6 of them had relation between symptoms and gastroesophageal reflux. Conclusion Patients with autoimmune gastritis may complain of GERD symptoms, including extraesophageal symptoms. 24-hour pH impedance monitoring is an ideal method for diagnosing gastroesophageal reflux and its association with symptoms. In any case, it is necessary to assess the total number of refluxes rather than AET.
Reference Key
openalex_W7203941994 Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Elen Valitova, О. И. Березина, Dmitry Bordin
Journal diseases of the esophagus : official journal of the international society for diseases of the esophagus
Year 2026
DOI
10.1093/dote/doag077.120
URL
https://doi.org/10.1093/dote/doag077.120
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