P1.165. Low Preoperative Fat-Free Mass Index Predicts Anastomotic Leakage and Poor Survival in Esophageal Cancer

Clicks: 2
ID: 325742
2026
Free PDF
Article Quality & Performance Metrics
Overall Quality
Not rated
Combines reader engagement with the AI quality analysis. This article has not been analysed, so there is no overall score — reader engagement is measured and shown alongside.
AI Quality Assessment
Not analyzed
Readership in this journal
Emerging

Ranked #367 of 453 articles by views in diseases of the esophagus : official journal of the international society for diseases of the esophagus

Most read Least read

Bar heights use a square-root scale. Only the 120 most-read articles are drawn; the journal has 453 in total.

Mint this article as an NFT
Not yet minted

Create a permanent, verifiable on-chain record of this article on the Scimatic Network. The NFT is held in your Journament account, and you can withdraw it to your own wallet at any time.

5 SUSD one-off · no wallet required
Sign in to mint
Abstract
Abstract Topic Esophageal Cancer: Surgical Treatment of Esophageal Cancer – long term outcomes Background Esophageal cancer is one of the most common gastrointestinal malignancies worldwide. In China, most patients are diagnosed at intermediate and advanced stages, and the treatment mainly includes neoadjuvant therapy, surgery and postoperative adjuvant therapy. Although the therapeutic effect has been greatly improved, clinical challenges still exist. Therefore, it's urgent to explore new and effective prognostic markers to identify high-risk patients at an early stage.Studies have shown that low preoperative fat-free mass index is an independent prognostic factor in several malignant tumors. However, its impact on anastomotic leakage and long-term prognosis in esophageal cancer patients remains rarely reported. Methods From January 2013 to December 2016, 411 patients who underwent radical resection for esophageal cancer were enrolled in this study. We divided patients into a low FFMI group and a high FFMI group by using the median values of FFMI for both males and females. To determine the discriminative ability of FFMI on the occurrence of anastomotic leakage after surgery, receiver operating characteristic curve (ROC) analysis was used. And then, area under curve (AUC) and 95% confidence interval (95% CI) were calculated. Kaplan Meier survival analysis was used to explore the impact of different FFMI groups on the overall survival (OS) and disease-free survival (DFS) of esophageal cancer patients, incorporating variables with significant differences (P<0.05) in the univariate Cox regression analysis into the multivariate Cox regression analysis. Results Our cohort included 245 males (59.61%) and 166 females (40.39%), with mean FFMI of 18.14±1.35 and 15.30±1.06 kg/m2, respectively. Patients were divided into low and high FFMI groups according to gender-specific median values. The overall postoperative anastomotic leakage rate was 9.98%. The low FFMI group showed significantly higher leakage rates in both males and females (males: 16.26% vs. 4.92%, P=0.004; females: 16.87% vs. 1.20%, P=0.025). Postoperative hospital stay was significantly longer in the low FFMI group for both genders (males: 15.26±9.47 vs. 12.82±6.14 days, P=0.017; females: 14.64±10.39 vs. 11.07±3.87 days, P=0.004). Kaplan–Meier analysis revealed that low FFMI was associated with poorer 5-year OS and DFS (OS: 37.4% vs. 50.2%, P=0.002; DFS: 32.0% vs. 43.9%, P=0.008). Multivariate Cox regression demonstrated that FFMI was an independent prognostic factor for OS (HR=0.73; 95%CI: 0.58–0.92; P=0.009) and DFS (HR=0.79; 95%CI: 0.64–0.98; P=0.031). Conclusion Our study found that preoperative low FFMI is a high-risk factor for increased risk of postoperative anastomotic leakage and poor survival prognosis in esophageal cancer patients. Therefore, in clinical practice, by early identification of patients with preoperative low FFMI and adopting related nutritional support and functional exercise treatments, the occurrence of poor prognosis associated with preoperative low FFMI can be reduced.
Reference Key
openalex_W7203934363 Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Jiarong Zhang, Weiming Chen, Weikun Su, Ruirong Lin, Y M Lin, Guibin Weng, Lin Chen, Weimin Fang
Journal diseases of the esophagus : official journal of the international society for diseases of the esophagus
Year 2026
DOI
10.1093/dote/doag077.313
URL
https://doi.org/10.1093/dote/doag077.313
Keywords Keywords not found

Citations

No citations found. To add a citation, contact the admin at info@scimatic.org

Comments

No comments yet. Be the first to comment on this article.