P1.121. Overall Survival in Patients With Locally Advanced Esophageal Squamous Cell Carcinoma Who Did Not Undergo Surgery After Neoadjuvant Chemoradiotherapy

Clicks: 1
ID: 325683
2026
Free PDF
Article Quality & Performance Metrics
Overall Quality
Not rated
Combines reader engagement with the AI quality analysis. This article has not been analysed, so there is no overall score — reader engagement is measured and shown alongside.
AI Quality Assessment
Not analyzed
Readership in this journal

Ranked #114 of 453 articles by views in diseases of the esophagus : official journal of the international society for diseases of the esophagus

Most read Least read

Bar heights use a square-root scale. Only the 120 most-read articles are drawn; the journal has 453 in total.

Mint this article as an NFT
Not yet minted

Create a permanent, verifiable on-chain record of this article on the Scimatic Network. The NFT is held in your Journament account, and you can withdraw it to your own wallet at any time.

5 SUSD one-off · no wallet required
Sign in to mint
Abstract
Abstract Topic Esophageal Cancer: Oncology/Radiation Therapy Background The standard treatment for locally advanced esophageal squamous cell carcinoma (ESCC) typically includes neoadjuvant concurrent chemoradiotherapy (CCRT) followed by surgical resection. However, not all patients undergo surgery for several reasons. This study evaluated the outcomes in patients with locally advanced ESCC who did not undergo surgery. Methods We evaluated patients with locally advanced ESCC who underwent neoadjuvant CCRT (fluorouracil and cisplatin) without subsequent surgical resection. Patient demographics, tumor characteristics, treatment details, and survival outcomes were analyzed. Results In total, 182 patients who underwent neoadjuvant CCRT were included in the analysis. The median overall survival (OS) was 13.0 months. Among patients who did and did not undergo surgery, 30 patients who achieved a complete clinical response (cCR) to neoadjuvant CCRT but did not proceed to surgery had significantly improved outcomes (OS=5.21 years) compared to 30 patients who underwent surgery (OS=1.79 years), 12 patients refused surgery (OS=1.63 years), 58 patients had unresectable disease (OS=0.71 years), and 52 patients were unfit for surgery (OS=0.67 years). In addition, the survival analysis, including potentially confounding variables, each treatment after CCRT was significant for OS. Conclusion cCR after neoadjuvant CCRT without subsequent surgery can result in favorable outcomes in patients with locally advanced ESCC. These findings support the potential role of CCRT as an optional treatment modality in patients with a cCR.
Reference Key
openalex_W7203876639 Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Somkiat Sunpaweravong, Song Limpchowfar, Apawee Tantawanit
Journal diseases of the esophagus : official journal of the international society for diseases of the esophagus
Year 2026
DOI
10.1093/dote/doag077.269
URL
https://doi.org/10.1093/dote/doag077.269
Keywords Keywords not found

Citations

No citations found. To add a citation, contact the admin at info@scimatic.org

Comments

No comments yet. Be the first to comment on this article.