What is the best dialysis regimen for severe AKI to allow kidney function recovery?
Clicks: 3
ID: 325594
2026
Article Quality & Performance Metrics
Overall Quality
Not rated
Combines reader engagement with the AI quality analysis. This
article has not been analysed, so there is no overall score —
reader engagement is measured and shown alongside.
Reader Engagement
Emerging Content
0.3
/100
3 views
1 readers
AI Quality Assessment
Not analyzed
Readership in this journal
EmergingRanked #93 of 128 articles by views in clinical kidney journal
Most read
Least read
Bar heights use a square-root scale. Only the 120 most-read articles are drawn; the journal has 128 in total.
Mint this article as an NFT
Not yet mintedCreate a permanent, verifiable on-chain record of this article on the Scimatic Network. The NFT is held in your Journament account, and you can withdraw it to your own wallet at any time.
5
SUSD
one-off · no wallet required
Abstract
Abstract Acute kidney injury (AKI) recovery is a major determinant of long-term renal and patient outcomes. While transient AKI is associated with a more favorable prognosis, persistent or incomplete recovery increases the risk of chronic kidney disease, dialysis dependence, cardiovascular complications, and mortality. Renal recovery after AKI reflects the balance between adaptive repair processes and maladaptive pathways leading to fibrosis and nephron loss. Experimental and clinical evidence highlights the roles of tubular epithelial regeneration, macrophage phenotypes, inflammatory mediators, complement activation, and aging-related decline in regenerative capacity in determining recovery trajectories. Recurrent injury and persistent hemodynamic stress may further impair renal repair and promote progression to chronic kidney disease. Renal replacement therapy (RRT) may itself contribute to delayed renal recovery through ‘dialytrauma,’ a concept that encompasses all harmful adverse events related to RRT. Major mechanisms of dialytrauma include hemodynamic instability and organ ischemia, blood–membrane inflammatory activation, metabolic and osmotic perturbations, and access-related complications. Intermittent hemodialysis is particularly associated with circulatory and osmotic stress, whereas continuous renal replacement therapy may expose patients to prolonged extracorporeal circulation, anticoagulation-related complications, and cumulative metabolic derangements. Peritoneal dialysis avoids extracorporeal blood contact but has other potential risks. This review summarizes the current understanding of dialytrauma as a potentially modifiable determinant of non-recovery of renal function in patients with AKI receiving RRT. No single modality is universally superior, and minimizing unnecessary exposure, excessive intensity, and hemodynamic instability is essential. In this article, we discuss strategies to minimise the risk of dialytrauma to guide individualized RRT strategies with the aim to promote renal recovery and preserve long-term kidney health.
| Reference Key |
openalex_W7203797332
Use this key to autocite in the manuscript while using
SciMatic Manuscript Manager or Thesis Manager
|
|---|---|
| Authors | Yu‐Ting Chou, Charles Jun Han Ng, Vin‐Cent Wu, Д. В. Соколов, Turgay Saritas, Marlies Ostermann |
| Journal | clinical kidney journal |
| Year | 2026 |
| DOI |
10.1093/ckj/sfag278
|
| URL | |
| Keywords | Keywords not found |
Citations
No citations found. To add a citation, contact the admin at info@scimatic.org
Comments
No comments yet. Be the first to comment on this article.