Physiological effects of pear ( Pyrus pyrifolia var. culta ) leaf extract on Caenorhabditis elegans

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ID: 325558
2026
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Abstract
The leaves of Japanese pear (Pyrus pyrifolia var. culta) are rich in polyphenols, but are mostly discarded as agricultural waste. In this study, we investigated the effects of pear leaf extract (PLE) on the lifespan and stress resistance of the nematode Caenorhabditis elegans. PLE significantly extended the lifespan of wild-type N2 worms. Mechanistic analyses using mutant strains and transgenic reporters revealed that PLE-induced lifespan extension requires SIR-2.1 and partially involves the insulin/IGF-1 signaling pathway via DAF-16. Furthermore, PLE enhances oxidative stress resistance via the SKN-1 pathway. Liquid chromatography-tandem mass spectrometry analysis demonstrated that chlorogenic acid, a major polyphenol in PLE, was directly taken up by nematodes. These findings suggest that the valorization of pear leaves as a functional dietary source could promote health span and mitigate age-related decline.
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openalex_W7203771333 Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Haruka Senda, Hiraki Yusei, Kodama Motoichiro, Atsushi Ishihara, Yukinori Yabuta
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Journal bioscience biotechnology and biochemistry
Year 2026
DOI
10.1093/bbb/zbag125
URL
https://doi.org/10.1093/bbb/zbag125
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