Redefining long-lived plasma cells by timestamping: isotype- and tissue-specific logic of plasma cell longevity
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ID: 325545
2026
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Abstract
Abstract Long-lived plasma cells have traditionally been viewed through the lens of bone marrow-resident IgG-secreting cells that maintain systemic serological memory. However, recent timestamping approaches and isotype-specific analyses have revealed diverse trajectories toward plasma-cell longevity. Plasma-cell longevity is not specified at a single developmental checkpoint, but emerges through a multi-step process involving the timing and site of plasma-cell generation, migratory competence, entry into and adaptation to tissue niches, and progressive maturation. Moreover, emerging studies of non-IgG plasma cells indicate that distinct antibody isotypes use different anatomical and molecular strategies to sustain antibody production. In particular, the recent identification of IgE long-lived plasma cells in secondary lymphoid tissues suggests that the bone marrow is not the only anatomical site capable of supporting durable plasma-cell survival. Together, these findings argue against a single, universal model of plasma-cell longevity and instead support a framework in which antibody persistence is achieved through isotype-specific and tissue-specific logic.
| Reference Key |
openalex_W7203770834
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|---|---|
| Authors | Wataru Ise |
| Journal | international immunology |
| Year | 2026 |
| DOI |
10.1093/intimm/dxag046
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| URL | |
| Keywords | Keywords not found |
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