Sorbic acid prevents tunicamycin-induced endoplasmic reticulum stress and Ire1–Hac1 pathway activation in Saccharomyces cerevisiae
Clicks: 3
ID: 325533
2026
Article Quality & Performance Metrics
Overall Quality
Not rated
Combines reader engagement with the AI quality analysis. This
article has not been analysed, so there is no overall score —
reader engagement is measured and shown alongside.
Reader Engagement
Emerging Content
0.6
/100
3 views
2 readers
AI Quality Assessment
Not analyzed
Readership in this journal
EmergingRanked #54 of 65 articles by views in bioscience biotechnology and biochemistry
Most read
Least read
Bar heights use a square-root scale.
Mint this article as an NFT
Not yet mintedCreate a permanent, verifiable on-chain record of this article on the Scimatic Network. The NFT is held in your Journament account, and you can withdraw it to your own wallet at any time.
5
SUSD
one-off · no wallet required
Abstract
Sorbic acid is a widely used food preservative recognized for its potent fungistatic effects, yet its specific mechanisms of action remain poorly understood. While investigating its effects on yeast organelles, we found that fungistatic concentrations of sorbic acid do not disturb homeostasis within the endoplasmic reticulum (ER). This contrasts with acetic acid, which induces ER stress despite having a similar dissociation constant, suggesting that ER disturbance is unlikely to be central to the fungistatic mechanism of sorbic acid. Unexpectedly, we discovered that sorbic acid prevents the induction of ER stress and the unfolded protein response (UPR) by tunicamycin. Sorbic acid abrogates activation of the Ire1-Hac1 pathway when administered prior to or during tunicamycin treatment, although it cannot suppress an already-induced UPR. These findings provide new insights into the physiological effects of sorbic acid on the yeast ER and the mechanism of action of tunicamycin.
| Reference Key |
openalex_W7203746815
Use this key to autocite in the manuscript while using
SciMatic Manuscript Manager or Thesis Manager
|
|---|---|
| Authors | Yuki Namekata, Yukio Kimata, Shingo Izawa |
| Journal | bioscience biotechnology and biochemistry |
| Year | 2026 |
| DOI |
10.1093/bbb/zbag126
|
| URL | |
| Keywords | Keywords not found |
Citations
No citations found. To add a citation, contact the admin at info@scimatic.org
Comments
No comments yet. Be the first to comment on this article.