Targeting dermatophyte clinical isolates: Lippia grata Schauer essential oil exhibits in vitro antifungal and antibiofilm activities

Clicks: 14
ID: 325409
2026
Free PDF
Article Quality & Performance Metrics
Overall Quality
Not rated
Combines reader engagement with the AI quality analysis. This article has not been analysed, so there is no overall score — reader engagement is measured and shown alongside.
AI Quality Assessment
Not analyzed
Readership in this journal
Emerging

Ranked #77 of 185 articles by views in Journal of applied microbiology

Most read Least read

Bar heights use a square-root scale. Only the 120 most-read articles are drawn; the journal has 185 in total.

Mint this article as an NFT
Not yet minted

Create a permanent, verifiable on-chain record of this article on the Scimatic Network. The NFT is held in your Journament account, and you can withdraw it to your own wallet at any time.

5 SUSD one-off · no wallet required
Sign in to mint
Abstract
AIMS: Dermatophytes are a closely related group of fungi affecting approximately 25% of the global population. These pathogens are becoming increasingly resistant to antifungal agents, leading to recalcitrant infections. Therefore, there is an urgent need to identify new compounds with antifungal potential, particularly among those derived from plant sources. The present study aimed to evaluate the in vitro antifungal and antibiofilm activity of Lippia grata essential oil (LgEO) against eight dermatophyte clinical isolates. MATERIALS AND METHODS: LgEO was extracted, and chemically characterized by GC-MS. Antifungal activity was evaluated by determining the Minimum Inhibitory Concentration (MIC) and the Minimum Fungicidal Concentration (MFC), while antibiofilm activity was assessed using crystal violet staining and scanning electron microscopy (SEM). RESULTS: LgEO yield was 2.45%, while four major phytoconstituents were identified: carvacrol (46.56%), thymol (16.35%), p-cymene (13.52%), and γ-terpinene (7.75%). MIC values ranged from 48.82 µg ml-1 to 390.62 µg ml-1, and MFC values ranged from 48.82 µg ml-1 to 781.25 µg ml-1, demonstrating a fungicidal effect. All isolates were strong biofilm producers, and the percentage of biofilm inhibition by LgEO ranged from 29.94% to 89.52%. Microscopic analysis revealed morphological alterations in conidia, hyphae, and the exopolysaccharide matrix, including cell disruption, particularly during biofilm formation. CONCLUSION: Overall, LgEO demonstrated strong antifungal and antibiofilm activities, supporting further studies aimed at developing antiseptic products and topical antifungal drugs for the treatment of dermatophytoses.
Reference Key
openalex_W7203834726 Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Fábio do Nascimento Sales, Joama Rebouças, Simone Nataly Busato de Feiria, Nalu Teixeira de Aguiar Peres, Renata Mendonça Araújo, Cynthia Cavalcanti de Albuquerque, Vânia Sousa Andrade
Journal Journal of applied microbiology
Year 2026
DOI
10.1093/jambio/lxag206
URL
https://doi.org/10.1093/jambio/lxag206
Keywords Keywords not found

Citations

No citations found. To add a citation, contact the admin at info@scimatic.org

Comments

No comments yet. Be the first to comment on this article.