Effect of shortening Ω-loop D on 3D domain swapping in cytochrome c

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ID: 325083
2026
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Abstract
Abstract Three-dimensional domain swapping (3D-DS) properties of wild-type human cyt c and its variants, in which one to five residues were deleted from Ω-loop D, were investigated. The cyt c dimer stability generally decreased as more amino acids were deleted from Ω-loop D. However, the del82-85 dimer exhibited a relatively small dissociation rate constant and hydrodynamic size, indicating that protein–protein interactions between the functional globular units play a crucial role in determining the stability of the 3D-DS dimer.
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openalex_W7203648386 Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Kotori Ota, Myriam Mahoudi, Tsuyoshi Mashima, Shun Hirota
Journal phytochemistry letters
Year 2026
DOI
10.1093/chemle/upag163
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