The Association Between Metabolic Score for Insulin Resistance and the Risk of Hypertension

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ID: 324989
2026
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Abstract
Abstract Objectives To systematically investigate the association and dose-response relationship between the metabolic score for insulin resistance (METS-IR) and the risk of hypertension, using data from a prospective cohort study of Chinese adults. Methods A total of 4866 adults without baseline hypertension were enrolled from the 2009 China Health and Nutrition Survey (CHNS) and followed up for 6 years to observe new-onset hypertension. Multivariable logistic regression, restricted cubic spline analysis, and subgroup analyses were employed to comprehensively evaluate the relationship between METS-IR and hypertension risk. Results During follow-up, 1256 participants developed hypertension. Multivariable logistic regression analysis showed that METS-IR was an independent risk factor for hypertension. As a continuous variable, METS-IR showed a positive correlation with hypertension risk (OR = 1.03, 95% CI, 1.02-1.05, P <.001). In quartile analyses, compared with the lowest quartile, the highest quartile of METS-IR was associated with increased hypertension risk (OR = 1.73, 95% CI, 1.37-2.18, P <.001). Restricted cubic spline analysis confirmed a linear correlation between METS-IR and hypertension risk (Pnonlinear = .388). Subgroup analyses indicated no significant interaction effects of sex, smoking, alcohol consumption, region, body mass index, or age on this association (all P for interaction >.05). Conclusions Metabolic score for insulin resistance serves as an independent risk factor for hypertension, with elevated levels demonstrating a robust positive correlation with hypertension risk.
Reference Key
openalex_W7203440241 Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Chen Yuang, Song Yue, Changqiang Yang
Journal American Journal of Hypertension
Year 2026
DOI
10.1093/ajh/hpaf211
URL
https://doi.org/10.1093/ajh/hpaf211
Keywords Keywords not found

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