Somatic alterations in TP53 , PIK3CA , and CCND1 reveal exposure-driven patterns in oral and oropharyngeal tumors

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ID: 324964
2026
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Abstract
Abstract Tobacco, alcohol, and human papillomavirus (HPV) are major risk factors for oral cavity (OC) and oropharyngeal (OPC) cancers, yet their specific contributions to the tumor molecular landscape remain incompletely understood. We analyzed somatic alterations in 1,086 tumors (606 OC, 480 OPC, including 287 HPV(+)OPC) profiled with a 1,109-gene panel and evaluated their associations with exposures. PIK3CA alterations were widespread but context-specific: HPV(+)OPC featured APOBEC-driven mutations and co-occurrence of FGFR3 mutations in a subset of cases, while HPV(-)OPC and OC were marked by 3q26/28 (PIK3CA/TP63/SOX2) amplifications. TP53 was the most frequently mutated gene in HPV(-) tumors, with strong enrichment among smokers in HPV(-)OPC, whereas TP53 mutation frequencies in OC were consistently high regardless of smoking status. CCND1 amplifications were largely restricted to HPV(-) tumors and were most frequent in individuals reporting combined tobacco/alcohol use. This combined effect was replicated in the TCGA OC-OPC cohort and mirrored at the transcriptomic level, where CCND1 mRNA expression was highest in dual users. Within OC, characterization of one of the largest cohorts of tumors from never smoker-never drinkers to date (N = 100) showed they were more likely to be from female patients and to exhibit enrichment for FAT1 and CASP8 mutations compared to tumors from ever smoker-ever drinkers (N = 353). Together, these findings define distinct, exposure-driven patterns of somatic alterations by subsite and HPV status, and provide a molecular framework that may inform etiologic-based risk stratification in head and neck cancer.
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Authors Ricardo Cortez Cardoso Penha, Shama Virani, Jeremiah Holt, Xiaobei Zhao, Paul Little, Myriam Brossard, Valérie Gaborieau, Maja Milojevic, Laura Torrens, Hanla A. Park, Tom Dudding, Wendell G. Yarbrough, Miranda Pring, Vonn Walter, Scott V. Bratman, Wolfgang Ahrens, Laia Alemany, Cristina Canova, David I. Conway, Claire M. Healy, Ivana Holcátová, Luís Felipe Ribeiro Pinto, María Paula Curado, Sandra Ventorin von Zeidler, Jose Carlos de Oliviera, José Roberto Vasconcelos de Podestá, Marta Vilensky, Areti Lagiou, Gary J. Macfarlane, Jerry Polesel, Lorenzo Richiardi, Max Robinson, Ariana Znaor, Jose Zevallos, Sandra Perdomo, Paul Brennan, Rayjean J. Hung, Tim Waterboer, Geoffrey Liu, Andrew F Olshan, Brenda Diergaarde, D Neil Hayes, James McKay
Journal JNCI Journal of the National Cancer Institute
Year 2026
DOI
10.1093/jnci/djag267
URL
https://doi.org/10.1093/jnci/djag267
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