Influenza Vaccination and Symptom Burden in Ambulatory Patients with Confirmed Influenza: Evidence from Case-ascertained Household Transmission Studies

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2026
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Ranked #212 of 635 articles by views in Clinical infectious diseases : an official publication of the Infectious Diseases Society of America

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Abstract
Abstract Background The extent to which influenza vaccination may temper disease remains uncertain. We compared symptoms between influenza vaccinated and unvaccinated ambulatory persons with influenza. Methods We conducted household transmission studies across multiple US sites during consecutive influenza seasons from 2017-2018 through 2022-2023 (excluding 2020-2021 season with minimal influenza activity). We collected daily symptom diaries and respiratory specimens. Three scores were calculated, varying weights on specific symptoms: 1) influenza-like illness (ILI); 2) lower respiratory; and 3) all symptoms. For each score, we examined the daily mean score between those vaccinated and unvaccinated against influenza using weighted multivariable linear mixed effects and frailty models. Results Study included 869 children (41% vaccinated, 47% female, 58% white, non-Hispanic) and 653 adults (42% vaccinated, 65% female, 72% white, non-Hispanic) with laboratory-confirmed influenza. In multivariable analyses, the mean difference in the daily ILI score was -0.16 (95% CI: -0.32, -0.01) between vaccinated and unvaccinated children and -0.18 (95% CI: -0.34, -0.01) for the lower respiratory score. There was no significant difference among adults. Influenza vaccination was not associated with time to symptom alleviation among children. However, ILI symptom alleviation occurred earlier among vaccinated (HR: 1.30, 95% CI: 1.04, 1.62) adults. Conclusion Ambulatory children with influenza who were vaccinated experienced less ILI symptom burden compared to those who were not vaccinated against influenza, but vaccination was not associated with symptom duration. Conversely, among ambulatory adults with influenza, vaccination and symptom burden were not associated, but vaccination was associated with faster alleviation of ILI symptoms.
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Authors Amanda C. Howa, Yuwei Zhu, Trey McGonigle, Huong Q. Nguyen, Melissa S. Stockwell, Yvonne Maldonado, Karen Lutrick, Natalie M. Bowman, Suchitra Rao, Jonathan Schmitz, Son H. McLaren, Ellen Sano, Clea Sarnquist, Sara Goodman, Joshua G. Petrie, Kathy Pryor, Ayla Bullock, Amy Yang, Jessica E. Deyoe, Sheroi Johnson, Sarah E. Smith-Jeffcoat, Edwin J. Asturias, Kate Ellingson, Celibell Vargas, Natasha Halasa, James Chappell, Edward A. Belongia, Melissa A. Rolfes, Alexandra Mellis, H. Keipp Talbot, Carlos G. Grijalva, Respiratory Virus Transmission Network – Sentinel Study Group, Erica Anderson, Bryan Blette, Jorge Celedonio, Allison Chan, Daniel Chandler, Nicola Chiwandire, Sydney Cornelison, Brittany Creasman, Ryan Dalforno, Shawn Garbett, Sarah Gleason, Carlos Grijalva, Amanda Howa, Xiang Huang, Tiffany Israel, Andrea Ito, Emily Jookar, Judy King, Dandan Liu, Stephanie Longmire, Cara Lwin, Samuel Massion, Rendie McHenry, John Meghreblian, Lauren Milner, Maria Padilla-Azain, Alexis Perry, John Resser, Brianna Schibley-Laird, Lan Shi, In Hae Shi, Andrea Stafford Hintz, H. Keipp Talbot, Dayna Wyatt, Paige Yates, Panpan Zhang
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Journal Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
Year 2026
DOI
10.1093/cid/ciag486
URL
https://doi.org/10.1093/cid/ciag486
Keywords Keywords not found

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