Photocatalyzed defluoro-α-aminoalkylation of trifluoromethylarenes with tertiary amines

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ID: 324606
2026
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Ranked #727 of 822 articles by views in phytochemistry letters

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Abstract
Abstract We report the defluoro-α-aminoalkylation of trifluoromethylarenes with N-methyl-substituted tertiary amines using Ir(ppy)3 catalyst under visible-light irradiation. The resulting products were successfully converted into the corresponding unprotected primary amines via an oxidation/dealkylation sequence. This sequential transformation provides a practical route to bioactive compounds. Moreover, site-selective C−F bond transformation of perfluoroalkylarenes was achieved.
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openalex_W7202207691 Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors
Journal phytochemistry letters
Year 2026
DOI
10.1093/chemle/upag159
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