Pregnancy complications and birth outcomes in women with antiphospholipid antibodies: a Danish population-based cohort study

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ID: 324198
2026
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Abstract
OBJECTIVES: To provide the first population-based estimates of pregnancy complications, adverse birth outcomes, and venous thromboembolism (VTE) among clinically selected women undergoing antiphospholipid antibody (aPL) testing, and to examine how risks vary by aPL status. METHODS: We conducted a population-based cohort study in the Central Denmark Region (2012-2023), including pregnancies reaching GA10 in women with at least one aPL measurement before pregnancy. Pregnancies were classified by aPL status and APS-related outcomes were assessed according to the 2023 ACR/EULAR criteria. Generalized estimating equations were used to estimate risk ratios (RR), risk differences, and mean differences with 95% confidence intervals (CI). RESULTS: Among 2,961 pregnancies, 137 (4.6%) were aPL-positive. Positive aPL was not associated with spontaneous abortion between GA10 + 0 and 15 + 6 or unexplained fetal death before GA34 + 0. However, aPL-positive pregnancies had higher risks of intrauterine growth restriction
Reference Key
openalex_W7196927406 Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Kristina Laugesen, Jens Fuglsang, Anders Abildgaard
Journal Lara D. Veeken
Year 2026
DOI
10.1093/rheumatology/keag399
URL
https://doi.org/10.1093/rheumatology/keag399
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