Incremental prognostic value of standard modifiable risk factor burden across SPECT myocardial perfusion categories: a study of 38 917 patients

Clicks: 1
ID: 324185
2026
Free PDF
Article Quality & Performance Metrics
Overall Quality
Not rated
Combines reader engagement with the AI quality analysis. This article has not been analysed, so there is no overall score — reader engagement is measured and shown alongside.
AI Quality Assessment
Not analyzed
Readership in this journal

Ranked #96 of 96 articles by views in European Heart Journal - Cardiovascular Imaging

Most read Least read

Bar heights use a square-root scale.

Mint this article as an NFT
Not yet minted

Create a permanent, verifiable on-chain record of this article on the Scimatic Network. The NFT is held in your Journament account, and you can withdraw it to your own wallet at any time.

5 SUSD one-off · no wallet required
Sign in to mint
Abstract
Stress myocardial perfusion imaging with single-photon emission computed tomography (SPECT) is widely used for evaluating coronary artery disease (CAD), with total perfusion deficit (TPD) serving as a validated, automated quantitative predictor of cardiovascular events.1 Recently, attention has focused on the concept of standard modifiable cardiovascular risk factors (SMuRFs): hypertension, diabetes, dyslipidaemia, and smoking, as prognostic determinants in patients with acute coronary syndrome.2 However, whether SMuRF burden provides incremental prognostic value across SPECT perfusion categories remains unclear. This retrospective study included 38 917 patients without prior CAD referred for clinically indicated SPECT MPI at Houston Methodist Hospital. SPECT was performed per ASNC guidelines using exercise or pharmacological stress (regadenoson).3 TPD was quantified and patients were categorized as TPD = 0 (no perfusion burden), TPD >0 and ≤10% (intermediate), or TPD >10% (significant). SMuRFs: hypertension, diabetes, dyslipidaemia, and current smoking were summed (0–4). The primary endpoint was the composite of all-cause mortality or myocardial infarction. Multivariable Cox models were adjusted for age, sex, BMI, LVEF, ischaemia, and scar; incremental discrimination was assessed using the likelihood ratio test and Harrell's C-index.
Reference Key
openalex_W7201864149 Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Alaaeddine El Ghazawi, Maria Alwan, Ahmad El Yaman, Mahmoud Al Rifai, Mouaz H Al-Mallah
Journal European Heart Journal - Cardiovascular Imaging
Year 2026
DOI
10.1093/ehjci/jeag143
URL
https://doi.org/10.1093/ehjci/jeag143
Keywords Keywords not found

Citations

No citations found. To add a citation, contact the admin at info@scimatic.org

Comments

No comments yet. Be the first to comment on this article.