TPT 4.13 Negative Pressure Wound Therapy Improves Overall Morbidity in Diabetic Foot Ulcers Compared to Conventional Wound Dressings: A Systematic Review and Meta-Analysis

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ID: 324105
2026
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Abstract
Abstract Introduction The objective of this article is to compare negative pressure wound therapy (NPWT) and conventional wound dressing in the treatment of diabetic foot ulcers (DFU). Methods Standard medical databases such as MEDLINE, Embase, Pubmed, and Cochrane Library were searched to find randomized, controlled trials comparing NPWT and conventional wound dressings in the treatment of DFUs. All data were analysed using Review Manager Software 5.4, and the meta-analysis was performed with a random effect model analysis. Results A total of 18 studies were included (n=2076 participants), recruiting adult patients with DFA receiving either NPWT dressing or no NPWT. Using a random-effects model, NPWT resulted in a significantly higher number of healed wounds compared with standard dressings (Odds Ratio [OR]: 4.65; 95% confidence interval [CI] [1.90, 11.39], z = 3.36, P = 0.0008). Moreover, the number of amputations was significantly lower in the NPWT group (OR: 0.33; 95% CI [0.14, 0.74], z = 2.68, P = 0.007). Although NPWT led to a greater reduction in wound area, this difference did not reach statistical significance (P = 0.34). Similarly, wound healing time tended to be shorter with NPWT, though this was not statistically significant (P = 0.26). The granulation tissue formation rate was comparable between the two groups (P = 0.72). The incidence of wound infection and osteomyelitis was also similar in both groups (P = 0.92 and P = 0.37). Conclusions In patients with DFU, NPWT has been shown to improve healing and reduce amputations compared to no NPWT.
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Authors Wajeeh Ullah Mahmood, Rubeen Ahmad, Omar Lubbad, Christie Swaminathan, Marwara Iftikhar, Muhammad S Sajid
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Journal the british journal of surgery
Year 2026
DOI
10.1093/bjs/znag087.212
URL
https://doi.org/10.1093/bjs/znag087.212
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