Examining the role of extrachromosomal DNA in lung cancer

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ID: 324053
2026
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Abstract
Abstract The role of extrachromosomal DNA (ecDNA) in lung cancer, particularly in subjects who never smoked (LCINS), remains unclear. Examination of over 1200 whole-genome-sequenced lung cancers identified ecDNA in 18.9% of patients. Recurrent amplification of MDM2 and other oncogenes via ecDNA possibly drives a LCINS subset. Tumors harboring ecDNA showed worse overall survival than tumors harboring other focal amplifications. A strong association with whole-genome doubling suggests most ecDNA reflects genomic instability in treatment-naïve lung cancer.
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Authors Azhar Khandekar, Phuc H Hoang, Jens Luebeck, Marcos Díaz-Gay, Wei Zhao, John McElderry, Caleb Hartman, Mona Miraftab, Olivia W. Lee, Kara M Barnao, Kristine Jones, Amy Hutchinson, Belynda Hicks, Erik N. Bergstrom, Yang Yang, Martin A. Nowak, Nathaniel Rothman, Angela Cecilia Pesatori, Dario Consonni, Robert Homer, Marina K Baine, Lynette M Sholl, Philippe Joubert, Charles Leduc, William D Travis, Soo-Ryum Yang, Qing Lan, David C. Wedge, Lixing Yang, Stephen J Chanock, Tongwu Zhang, Ludmil B Alexandrov, Maria Teresa Landi
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Journal JNCI Journal of the National Cancer Institute
Year 2026
DOI
10.1093/jnci/djag273
URL
https://doi.org/10.1093/jnci/djag273
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