SP 8.13 Use Of Probiotics in Patients Undergoing Colorectal Resection Is Associated with Reduced Risk of Surgical Site Infections; A Meta-Analysis

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ID: 323927
2026
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Abstract
Abstract Aim The objective of this study is to check the efficacy of use of preoperative probiotics/synbiotics in reducing the surgical site infection in patients undergoing colorectal resection Methods Standard medical electronic databases were searched to find relevant randomised controlled trials by using the principles of meta-analysis. Statistical analysis was performed using RevMan software version 5.4. Results Twenty-four RCTs on 2155 patients undergoing colorectal resections, divided into two groups (those receiving probiotics/symbiotic pre-operatively and those receiving placebo/standard care). In the random effects random analysis, the use of preoperative probiotics/symbiotics is associated with reduced risk of surgical site infection [odds ratio 0.61 (95% CI 0.40, 0.95), Z=2.17, P= 0.03]. However, there was statistically significant heterogeneity (Tau=0.48, Chi= 43.5, df=22 (P=0.004)) among included randomised controlled trials. Conclusion Based upon the findings of the current meta-analysis, the use of preoperative probiotics/symbiotics in patients undergoing colorectal resection seems to have clinical advantage of lower risk of surgical site infection.
Reference Key
openalex_W7172527120 Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Yasser Mohamed, Fatima Zulfiqar, Winnie Lam, Christie Swaminathan, Mirza K Baig, Muhammad Sajid
Journal the british journal of surgery
Year 2026
DOI
10.1093/bjs/znag087.112
URL
https://doi.org/10.1093/bjs/znag087.112
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