TPW 8.14 Outcomes for Isolated Bowel Transplant Patients: A Retrospective Study of a Single Centre Experience

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ID: 323909
2026
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Abstract
Abstract Aim Intestinal transplant (ITx) is indicated in patients with irreversible intestinal failure and complications with parenteral nutrition (PN) such as intestinal failure associated liver disease (IFALD), loss of central venous access or recurrent line infections. Overall, outcomes of ITx have improved with surgical experience, improvement of immunosuppression and peri-operative care. However, ITx encompasses a range of operations including liver and non-liver containing grafts. The outcomes from these operations are often reported collectively. We aim to investigate outcomes after isolated small bowel transplants (ISBT). Method In this study, we performed retrospective analysis of outcomes after ISBT in adult patients with benign aetiologies, from a single UK transplant centre between 01/01/2008 – 01/07/2025. We analysed demographics, patient survival, incidence of rejection and complications such as Graft Vs Host Disease (GvHD) and Post-Transplant Lymphoproliferative disorders (PTLD). Results 43 patients underwent ITx during the study period, the mean age was 45.5 years (24-63). 1-year survival was 92.9%, 5-year survival was 71.2% and 10-year survival was 51.7%. Rejection occurred in 44% (35% grade 1, 23% grade 2, 42% grade 3). The mean ICU stay was 9 days (1-69), average length of stay was 60 days (20-369). There were 2 cases of PTLD and no cases of GvHD. Conclusion This study demonstrates good outcomes for ISBT, in a patient population with limited nutrition options due to complications from PN. Rejection rates remain high, but treatable. Separating outcomes into specific graft types gives more accurate outcome measures to aid patient and clinician decision making around intestinal transplant.
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Authors Abena Boatey, Charlotte Yates, Srikanth Reddy, Venkatesha Udupa, Philip Allan, Emilio Canovai
Journal the british journal of surgery
Year 2026
DOI
10.1093/bjs/znag087.401
URL
https://doi.org/10.1093/bjs/znag087.401
Keywords Keywords not found

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