TPW 7.14 When Weight Loss Hurts: An Observational Study of Emerging Biliary and Pancreatic Complications in Patients Receiving Tirzepatide (Mounjaro)

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ID: 323861
2026
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Abstract
Abstract Aim The study aims to interpret whether Tirzepatide (Mounjaro) use is associated with an increased risk of precipitating cholecystitis or pancreatitis in patients receiving GLP-1 therapy. Methods A single-cycle prospective audit was conducted over a seven-month period, reviewing patients receiving Tirzepatide (Mounjaro) who presented with abdominal pain. Data collected comprised patient age, gender, presence of type 2 diabetes mellitus, and current use of tirzepatide (Mounjaro). A second cycle is required to further explore and confirm the initial findings. Results The first audit cycle included 30 patients receiving the GLP-1 receptor agonist tirzepatide (Mounjaro) who presented with abdominal pain in the last 7 months. Five were male (16.7%), and 25 female (83.3%; female: male 5:1). The cohort was predominantly middle-aged: 12 patients (40.0%) were aged 21- 40 years and 14 (46.7%) were 41- 60 years, meaning 26 patients (86.7%) fell within the 21- 60 year age range. Four patients (13.3%) were aged 61–80 years. Six patients (20.0%) had type 2 diabetes, while 24 (80.0%) did not. Biliary or pancreatic pathology was identified in 15 patients (50.0%). New-onset biliary colic (n=8 ) was more frequent than exacerbation of gallstone disease (5 cases; ratio 1.6:1). Biliary-only disease (n = 13) greatly exceeded pancreatic involvement (2 cases; ratio 6.5:1). New-onset biliary colic accounted for 53.3% of pathology cases (26.7% overall). These findings show a strong signal of biliary pathology in the cohort. Conclusion Mounjaro use may be linked to abdominal pathology, particularly biliary colic, warranting the need for rigorous analysis.
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Authors Bidisha Singha, Omar Okkeh, Md Abu Kamal Nahid
Journal the british journal of surgery
Year 2026
DOI
10.1093/bjs/znag087.383
URL
https://doi.org/10.1093/bjs/znag087.383
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