Development and Application of an Anaerobic Activity Index

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ID: 323600
2026
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Ranked #284 of 635 articles by views in Clinical infectious diseases : an official publication of the Infectious Diseases Society of America

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Abstract
BACKGROUND: Antibiotics with anaerobic activity may result in adverse patient outcomes. Here, we report the development and application of an Anaerobic Activity Index (AAI) to quantify anti-anaerobic antibiotic exposure. METHODS: The numeric AAI was generated for 21 antibiotics using in vitro susceptibility data for seven anaerobic bacterial groups. A binning strategy was applied to susceptibility proportions to result in the fewest antibiotic tied scores. In a cohort of patients with burns, 7-day anaerobic exposure was calculated, multiplied by days of therapy, and summed. Multivariable logistic regression models assessed the association between AAI quartiles and a 90-day composite outcome including culture positivity with bacteria of interest, healthcare-associated infection, and/or death. RESULTS: We included 88 papers reporting on anaerobic activity. The AAI ranged from 4 to 59. Meropenem (59), ertapenem (58), and tigecycline (57) were the highest ranked antibiotics, whereas penicillin (20), doxycycline (13), and aztreonam (4) had the lowest scores. Several antibiotics could not be included for lack of data. In a cohort of patients with burns, the highest seven-day AAI quartile was associated with increased odds of the 90-day composite outcome compared to the lowest quartile (OR: 2.90; 95% CI: 1.65-5.08), adjusting for Baux score and Charlson comorbidity index. CONCLUSIONS: We propose an anaerobic activity index (AAI) assigning numeric scores to commonly used antibiotics. We anticipate that this score will require updating as additional susceptibility data become available. The AAI may be used as a research tool evaluating the impact of anti-anaerobic antibiotics on patient outcomes.
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Authors Natalie Mackow, Lauren Komarow, Sonia Napravnik, Tessa M. Andermann, Luther A. Bartelt, Lauren DiBiase, Billy Williams, Felicia Williams, Vincent B. Young, David M. Aronoff, David J Weber, Rishi Chanderraj, David van Duin
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Journal Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
Year 2026
DOI
10.1093/cid/ciag470
URL
https://doi.org/10.1093/cid/ciag470
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