A Technology-Blended Exercise Intervention for Cognitive Risk Reduction and Brain Health in Middle-Aged and Older Adults with Type 2 Diabetes in Singapore

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ID: 323579
2026
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Abstract
BACKGROUND: Type 2 diabetes mellitus (T2DM) is a major modifiable risk factor for accelerated brain ageing, cognitive decline, and dementia. However, sustainable lifestyle interventions targeting cognitive health in at-risk older adult populations remain limited. This mixed-methods study evaluated the effects of a 12-week technology-blended Intensive Aerobic and Resistance Exercise Program (IAREP) on cognitive risk and related health outcomes among middle-aged and older adults with T2DM in a primary care setting in Singapore. METHODS: Participants were recruited from a community polyclinic and allocated to either the intervention or usual care group. The intervention integrated face-to-face, Zoom-based, and video-recorded home exercise sessions to support accessibility and adherence. Quantitative outcomes included cognitive impairment risk, physical function, metabolic and inflammatory markers, physical activity, and self-care maintenance. Qualitative focus group discussions explored participant experiences following programme completion. RESULTS: Fifty-three participants completed the study (mean age 66.7 years). Compared with usual care, the intervention group demonstrated significant reductions in predicted risk of cognitive impairment (F(1,51)=4.9, p = 0.031, η²ₚ=0.088), improvements in physical function (F(1,51)=10.6, p = 0.002, η²ₚ=0.172), and higher physical activity levels (F(1,51)=8.3, p = 0.006, η²ₚ=0.140). Self-care maintenance also improved significantly (F(1,51)=4.5, p = 0.040, η²ₚ=0.081). Adherence was high (88.9%). Qualitative findings highlighted enhanced motivation, social connectedness, and perceived cognitive and physical well-being. CONCLUSION: These findings support technology-blended exercise might be a feasible and scalable strategy for cognitive risk reduction and brain health promotion among middle-aged and older adults with T2DM, with potential translational relevance for dementia prevention in primary care and community settings.
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Authors Jinghua Zhang, Wilson Tam, Jinhua Lu, Junjie Chen, Jed Montayre, Joji Kusuyama, Yanhong Dong, Xin Yi Yap, Wentao Zhou, Na Wang, Hui Nan Yeo, F. Lee, Xi Vivien Wu
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Journal the journals of gerontology series a, biological sciences and medical sciences
Year 2026
DOI
10.1093/gerona/glag192
URL
https://doi.org/10.1093/gerona/glag192
Keywords Keywords not found

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