Precision microbiome medicine and therapeutics: the enabling role of in vitro gut models

Clicks: 13
ID: 323256
2026
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Ranked #24 of 101 articles by views in FEMS microbiology reviews

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Abstract
Abstract The human gut microbiome exhibits profound interindividual variability, challenging the efficacy of generalized interventions and underscoring the need for precision approaches to microbiome-associated diseases. Such strategies require comprehensive, individualized assessment of microbial ecosystems and their functional responses, an objective that remains difficult to achieve in vivo. In vitro gut models offer a promising alternative, maintaining personalized microbial communities in controlled environments and enabling detailed investigation of microbiome dynamics. Complementary microbe–host co-culture systems incorporating human cells further permit mechanistic interrogation of host responses to microbial stimuli. Together, these integrated platforms offer a translational framework for developing tailored therapeutics. In this Perspective, we examine how in vitro gut models can advance microbiome-based personalized medicine, discuss key determinants of therapeutic variability, and outline the relevance, limitations, and future directions of these systems in designing targeted, more effective interventions.
Reference Key
openalex_W7172336737 Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Zhan Huang, Siew C Ng, Harry Sokol, Nathalie Rolhion
Journal FEMS microbiology reviews
Year 2026
DOI
10.1093/femsre/fuag038
URL
https://doi.org/10.1093/femsre/fuag038
Keywords Keywords not found

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