Effectiveness of opportunistic bilateral salpingectomy in preventing epithelial ovarian cancer: a population-based study
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ID: 323051
2026
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Abstract
BACKGROUND: Opportunistic bilateral salpingectomy (OBS), the removal of fallopian tubes during hysterectomy or instead of tubal ligation, is recommended to reduce ovarian cancer risk. However, data on the effectiveness of prophylactic OBS is limited. METHODS: This population-based retrospective cohort included individuals aged 18-80 in Ontario, Canada, who underwent OBS or comparator surgeries (hysterectomy with ovarian and tubal conservation or tubal ligation) from 2011 to 2023. Individuals with gynecologic cancer before or within six months of surgery were excluded. Hazard ratios and 95% confidence intervals were estimated using Cox proportional hazards regression. Sensitivity analyses varied the time between surgery and cancer diagnosis to account for pre-existing serous tubal intraepithelial carcinomas. RESULTS: Among 196,839 individuals, 57,941 underwent OBS and 138,898 underwent comparator surgeries. 142 epithelial ovarian cancers were diagnosed (19 in the OBS group and 123 in the comparator surgery group). OBS was associated with reduced risk of any ovarian carcinoma, with an adjusted hazard ratio (aHR) of 0.60 (95% CI, 0.36 to 0.98). For serous ovarian carcinoma (high- and low-grade combined due to missing grade data), the aHR was 0.47 (95% CI, 0.22 to 0.99). Sensitivity analyses with 12- and 18-month intervals showed aHRs of 0.59 (95% CI, 0.35 to 0.99) and 0.60 (95% CI, 0.35 to 1.01) for all ovarian carcinomas, and 0.49 (95% CI, 0.23 to 1.01) and 0.47 (95% CI, 0.22 to 0.99) for serous ovarian carcinoma, respectively. CONCLUSIONS: OBS was associated with reduced risk of ovarian carcinoma, supporting its role as a primary prevention strategy.
| Reference Key |
openalex_W7171799133
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| Authors | Foruzan Bahrami, Julianne McLeod, Celeste Leigh Pearce, Lawrence H Kushi, Christine Garcia, Paul J. Yong, Mary A. De Vera, Jessica N McAlpine, Jamie N Bakkum Gamez, Kristin M Tischer, David Huntsman, Gillian E Hanley |
| Journal | JNCI Journal of the National Cancer Institute |
| Year | 2026 |
| DOI |
10.1093/jnci/djag251
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| URL | |
| Keywords | Keywords not found |
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