Newly synthesized (E)-4-(2-chloro-1-(2-chloro-benzyl)-1H-indol-3-yl)but-3-en-2-one (SBA) induces apoptotic cell death through Fas-FasL and mitochondria-mediated pathways in human oral carcinoma SCC-4 cells
Clicks: 10
ID: 322851
2026
Article Quality & Performance Metrics
Overall Quality
Not rated
Combines reader engagement with the AI quality analysis. This
article has not been analysed, so there is no overall score —
reader engagement is measured and shown alongside.
Reader Engagement
Emerging Content
2.7
/100
10 views
9 readers
AI Quality Assessment
Not analyzed
Readership in this journal
EmergingRanked #31 of 70 articles by views in bioscience biotechnology and biochemistry
Most read
Least read
Bar heights use a square-root scale.
Mint this article as an NFT
Not yet mintedCreate a permanent, verifiable on-chain record of this article on the Scimatic Network. The NFT is held in your Journament account, and you can withdraw it to your own wallet at any time.
5
SUSD
one-off · no wallet required
Abstract
SBA, (E)-4-(2-chloro-1-(2-chloro-benzyl)-1H-indol-3-yl)but-3-en-2-one, is a derivative of natural product, named 4,4'-dimethoxychalcone. In this study, the impact of newly synthesized SBA on cell apoptosis was investigated in human oral cancer SCC-4 cells in vitro. The results showed that SBA decreased cell viability, induced S and G2/M phase arrest, and induced apoptosis in SCC-4 cells. SBA also increased ROS production, reduced mitochondrial membrane potential, and activated caspase-9 and caspase-3 in a dose-dependent manner. SBA induced the upregulation of Chk1 and Chk2 expressions, while it resulted in a reduction of cdc2 and Cyclin B1 levels. SBA also increased the levels of Fas, FasL, FADD, caspase-8, and BID. Moreover, it increased the expression of Bad, Bax, cytochrome c, AIF, EndoG, caspase-9, and caspase-3, while reducing the expression of Bcl-2, Bcl-xL, and XIAP in SCC-4 cells. Taken together, these findings suggest that SBA induces cytotoxicity in SCC-4 cells via Fas-FasL- and mitochondria-mediated pathways.
| Reference Key |
openalex_W7171505553
Use this key to autocite in the manuscript while using
SciMatic Manuscript Manager or Thesis Manager
|
|---|---|
| Authors | Yi-Shih Ma, Jin‐Cherng Lien, Fu-Shin Chueh, Yi-Ping Huang, Jiun-Long Yang, Yu‐Cheng Chou, Jaw-Chyun Chen, Yung‐Lin Chu, An-Cheng Huang, Tzu‐Shun Lin, Shu‐Fen Peng |
| Journal | bioscience biotechnology and biochemistry |
| Year | 2026 |
| DOI |
10.1093/bbb/zbag116
|
| URL | |
| Keywords | Keywords not found |
Citations
No citations found. To add a citation, contact the admin at info@scimatic.org
Comments
No comments yet. Be the first to comment on this article.