Efficient total synthesis of shancigusin C, first total synthesis of shancigusin D, and evaluation of their bioactivities
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ID: 322537
2026
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Abstract
Abstract First total synthesis of shancigusin D and an efficient total synthesis of shancigusin C were achieved starting from methyl 3,5-dimethoxybenzoate. This strategy employed the Wittig reaction to link the phenethyl component, and Friedel–Crafts acylation to attach the hydroxybenzyl moiety characteristic of shancigusins. Evaluation of their bioactivity indicates that shancigusins C and D exhibit notable inhibitory effects on degranulation and moderate activity in promoting neurite outgrowth.
| Reference Key |
openalex_W7171167463
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|---|---|
| Authors | Toshiro Noshita, Takeru Koga, Masashi Fukaya, Akihiro Tai |
| Journal | bioscience biotechnology and biochemistry |
| Year | 2026 |
| DOI |
10.1093/bbb/zbag117
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| URL | |
| Keywords | Keywords not found |
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