Efficient total synthesis of shancigusin C, first total synthesis of shancigusin D, and evaluation of their bioactivities

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ID: 322537
2026
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Abstract
Abstract First total synthesis of shancigusin D and an efficient total synthesis of shancigusin C were achieved starting from methyl 3,5-dimethoxybenzoate. This strategy employed the Wittig reaction to link the phenethyl component, and Friedel–Crafts acylation to attach the hydroxybenzyl moiety characteristic of shancigusins. Evaluation of their bioactivity indicates that shancigusins C and D exhibit notable inhibitory effects on degranulation and moderate activity in promoting neurite outgrowth.
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openalex_W7171167463 Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Toshiro Noshita, Takeru Koga, Masashi Fukaya, Akihiro Tai
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Journal bioscience biotechnology and biochemistry
Year 2026
DOI
10.1093/bbb/zbag117
URL
https://doi.org/10.1093/bbb/zbag117
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