Site-specific relapse in pemphigus is associated with localized tissue-resident memory T-cell enrichment
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ID: 322381
2026
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Abstract
Pemphigus relapse shows a non-random, site-specific pattern, with recurrent lesions preferentially occurring at previously affected anatomical locations. In a retrospective cohort of 105 patients, we found that spatial overlap between onset and relapse sites significantly exceeded random expectation and was independent of circulating autoantibody levels. Recurrent lesions were enriched for CD4+CD69+ and CD8+CD103+ tissue-resident memory T cells, suggesting a role for localized immune memory in disease recurrence.
| Reference Key |
openalex_W7170686796
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|---|---|
| Authors | Xueting Peng, Jialu Zhao, Shiran Kang, Yumin Xia, Yale Liu |
| Journal | the british journal of dermatology |
| Year | 2026 |
| DOI |
10.1093/bjd/ljag311
|
| URL | |
| Keywords | Keywords not found |
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