Vitamin D3 Prevents Calcium-Induced Progression of Early-Stage Prostate Tumors by Counteracting TRPC6 and Calcium Sensing Receptor Upregulation.

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ID: 32188
2017
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Abstract
Active surveillance has emerged as an alternative to immediate treatment for men with low-risk prostate cancer. Accordingly, identification of environmental factors that facilitate progression to more aggressive stages is critical for disease prevention. Although calcium-enriched diets have been speculated to increase prostate cancer risk, their impact on early-stage tumors remains unexplored. In this study, we addressed this issue with a large interventional animal study. Mouse models of fully penetrant and slowly evolving prostate tumorigenesis showed that a high calcium diet dramatically accelerated the progression of prostate intraepithelial neoplasia, by promoting cell proliferation, micro-invasion, tissue inflammation, and expression of acknowledged prostate cancer markers. Strikingly, dietary vitamin D prevented these calcium-triggered tumorigenic effects. Expression profiling and in vitro mechanistic studies showed that stimulation of PC-3 cells with extracellular Ca resulted in an increase in cell proliferation rate, store-operated calcium entry (SOCE) amplitude, cationic channel TRPC6, and calcium sensing receptor (CaSR) expression. Notably, administration of the active vitamin D metabolite calcitriol reversed all these effects. Silencing CaSR or TRPC6 expression in calcium-stimulated PC3 cells decreased cell proliferation and SOCE. Overall, our results demonstrate the protective effects of vitamin D supplementation in blocking the progression of early-stage prostate lesions induced by a calcium-rich diet. Cancer Res; 77(2); 355-65. ©2016 AACR.
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bernichtein2017vitamincancer Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Bernichtein, Sophie;Pigat, Natascha;Barry Delongchamps, Nicolas;Boutillon, Florence;Verkarre, Virginie;Camparo, Philippe;Reyes-Gomez, Edouard;Méjean, Arnaud;Oudard, Stéphane M;Lepicard, Eve M;Viltard, Mélanie;Souberbielle, Jean-Claude;Friedlander, Gérard;Capiod, Thierry;Goffin, Vincent;
Journal Cancer research
Year 2017
DOI
10.1158/0008-5472.CAN-16-0687
URL
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