Psoriasis patients with psoriatic arthritis demonstrate a reduced regulatory capacity for neutrophil elastase
Clicks: 2
ID: 321874
2026
Article Quality & Performance Metrics
Overall Quality
Not rated
Combines reader engagement with the AI quality analysis. This
article has not been analysed, so there is no overall score —
reader engagement is measured and shown alongside.
Reader Engagement
Steady Performance
0.3
/100
2 views
0 readers
AI Quality Assessment
Not analyzed
Readership in this journal
SteadyRanked #83 of 202 articles by views in Lara D. Veeken
Most read
Least read
Bar heights use a square-root scale. Only the 120 most-read articles are drawn; the journal has 202 in total.
Mint this article as an NFT
Not yet mintedCreate a permanent, verifiable on-chain record of this article on the Scimatic Network. The NFT is held in your Journament account, and you can withdraw it to your own wallet at any time.
5
SUSD
one-off · no wallet required
Abstract
OBJECTIVES: Identifying which patients with psoriasis (PsO) may develop psoriatic arthritis (PsA) is a research priority. We have previously shown that elafin along with IL-36g are excellent cutaneous biomarkers for PsO. The protease inhibitor elafin and its target protease, neutrophil elastase (NE), can be detected in both serum and epidermal samples. Our aims were to assess if known PsO biomarkers are expressed differentially in patients affected by plaque PsO with and without PsA. METHODS: Protein expression of NE and elafin were analysed in matched epidermal samples and serum of PsO, PsA patients and healthy controls. Findings were validated in independent PsA and arthritis cohorts. RESULTS: The ratio between NE and elafin differed significantly between PsO and PsA patients. Expression of elafin was reduced in PsA samples as compared to plaque PsO patients. The ratio of NE to secretory leukocyte protease inhibitor was also increased in PsA as compared to PsO patients with no PsA, healthy controls and other arthritis patients. CONCLUSIONS: PsA patients show a reduced NE inhibitor expression in both the skin and blood compartment compared to those with plaque PsO only. This may suggest differences in the ability to regulated neutrophil activity in PsA patients.
| Reference Key |
openalex_W7170060268
Use this key to autocite in the manuscript while using
SciMatic Manuscript Manager or Thesis Manager
|
|---|---|
| Authors | Tom Macleod, Sayam Dubash, Isabel Hyde, Xabier Michelena, Anna Berekméri, Helliwell Ps, Sarah R. Kingsbury, P Laws, Kulveer Mankia, Martin Stacey, Helena Marzo-Ortega, Miriam Wittmann |
| Journal | Lara D. Veeken |
| Year | 2026 |
| DOI |
10.1093/rheumatology/keag369
|
| URL | |
| Keywords | Keywords not found |
Citations
No citations found. To add a citation, contact the admin at info@scimatic.org
Comments
No comments yet. Be the first to comment on this article.