Degradable Endometrial Repair Membrane (DERM) promoted the endometrial regeneration in intrauterine adhesions therapy

Clicks: 7
ID: 321791
2026
Free PDF
Article Quality & Performance Metrics
Overall Quality
Not rated
Combines reader engagement with the AI quality analysis. This article has not been analysed, so there is no overall score — reader engagement is measured and shown alongside.
AI Quality Assessment
Not analyzed
Readership in this journal

Ranked #47 of 124 articles by views in biology of reproduction

Most read Least read

Bar heights use a square-root scale. Only the 120 most-read articles are drawn; the journal has 124 in total.

Mint this article as an NFT
Not yet minted

Create a permanent, verifiable on-chain record of this article on the Scimatic Network. The NFT is held in your Journament account, and you can withdraw it to your own wallet at any time.

5 SUSD one-off · no wallet required
Sign in to mint
Abstract
Abstract Following injury from medical procedures or infections, the endometrium may fail to regenerate, leading to the formation of scar tissue that results in intrauterine adhesion, potentially disrupting normal endometrial function and contributing to infertility. Regenerative medicine is regarded as a promising solution to this concern, potentially providing effective treatment methods for the regeneration of injured human endometrium. Herein, we fabricated a degradable endometrial repair membrane (DERM) mainly composed of extracellular matrix, which acts as an intrauterine physical barrier and supports endometrial regeneration. In this study, we explored the role of DERM in epithelial transformation, anti-fibrosis, and angiogenesis using both an in vitro cell model and an in vivo electrothermal-induced rabbit IUA model. In vitro, the DERM effectively reduced the expression of fibrosis markers (FN1, COL1A1 and α-SMA) while promoting the expression of epithelial-related markers (CDH1 and CK19) in primary human endometrial stromal cells (HESCs) and angiogenesis-related factors (VEGFA and VEGFR2) in HUVECSs. The rabbit electrothermal injury model was used to mimic clinical electrosurgical adhesiolysis. In vivo, HE staining revealed DERM significantly accelerated endometrial regeneration, angiogenesis, and restored uterine functionality; Masson staining confirmed the deposition of collagen in endometrium of rabbits was notably reduced following the DERM treatment. Moreover, DERM remarkbly upregulated CDH1 and CK19 expression, and gradually degraded in the uterine cavity to avoid inflammatory irritation. In conclusion, the DERM facilitated the repair and regeneration of the endometrium, suggesting a promising new therapeutic approach for endometrial repair.
Reference Key
openalex_W7169867853 Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Huishan Zhao, Shunzhi He, Wencai Zhang, Mingwei Yu, Hongchu Bao
Journal biology of reproduction
Year 2026
DOI
10.1093/biolre/ioag151
URL
https://doi.org/10.1093/biolre/ioag151
Keywords Keywords not found

Citations

No citations found. To add a citation, contact the admin at info@scimatic.org

Comments

No comments yet. Be the first to comment on this article.