Endometrial gland secretome maintains the homeostasis of decidualization

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ID: 321417
2026
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Abstract
Decidualization of human endometrial stromal cells (hESCs) during the secretory phase is critical for implantation and pregnancy. In this study, we assessed 25 established in vitro decidualization markers using in vivo single-cell transcriptomic data and found that the expression levels of most of them, including PRL and IGFBP1, were comparable between the proliferative- and secretory-phase hESCs or between the decidualized and non-decidualized hESCs. We hypothesized that the lack of endometrial glands in vitro causes the discrepancy. However, the role of the endometrial glands in decidualization remains unclear. Using a co-culture model, we demonstrated that the secretome of human endometrial organoids attenuates decidualization by reducing canonical marker upregulation and hESC mesenchymal-epithelial transition. Transcriptomic analysis revealed the downregulation of key decidualization regulators CEBPA and EDN1. Consistent with the in vitro findings, an estradiol-stimulated mouse model with increased glandular formation showed reduced decidualization. Collectively, our results identify a novel homeostatic function of endometrial gland secretome in decidualization regulation.
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openalex_W7169559384 Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Leqian Lin, Xintong Li, Y.-T. Li, Jianlin Li, Kunfeng Bai, Kun Wang, Q Zhang, Yu Li, Yeung Ws, Jian Zhang, Yuanqing Yao, Cheuk‐Lun Lee, Philip C.N. Chiu
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Journal journal of molecular cell biology
Year 2026
DOI
10.1093/jmcb/mjag023
URL
https://doi.org/10.1093/jmcb/mjag023
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