Kidney-infiltrating proteinase 3-positive granulocytes are abundant in lupus nephritis

Clicks: 2
ID: 321366
2026
Free PDF
Article Quality & Performance Metrics
Overall Quality
Not rated
Combines reader engagement with the AI quality analysis. This article has not been analysed, so there is no overall score — reader engagement is measured and shown alongside.
AI Quality Assessment
Not analyzed
Readership in this journal
Emerging

Ranked #127 of 202 articles by views in Lara D. Veeken

Most read Least read

Bar heights use a square-root scale. Only the 120 most-read articles are drawn; the journal has 202 in total.

Mint this article as an NFT
Not yet minted

Create a permanent, verifiable on-chain record of this article on the Scimatic Network. The NFT is held in your Journament account, and you can withdraw it to your own wallet at any time.

5 SUSD one-off · no wallet required
Sign in to mint
Abstract
Abstract Objectives Active proliferative lupus nephritis (LN) is associated with elevated urinary neutrophil granule proteins such as proteinase 3 (PR3), implicating active cellular degranulation in LN. Yet, mature neutrophils are rarely observed in LN biopsies, raising the possibility of an unrecognized cellular source. We aimed to identify and characterize PR3-expressing myeloid cells in LN kidneys using a spatially resolved multi-omics approach. Methods Serial immunohistochemistry (10-plex) and spatial transcriptomics were employed to assess the distribution of PR3+ cells across renal tissue and characterize their cellular phenotype. Results PR3+ cells were abundant in LN kidney biopsies, but with marked inter-patient heterogeneity. These cells were predominantly localized to the tubulointerstitium and showed similar distribution in both proliferative and membranous LN. In contrast, intraglomerular PR3+ cells were enriched in proliferative LN and correlated with the NIH Activity Index. Phenotype analysis identified four subsets of PR3+ cells, consistent with a monocyte/neutrophil lineage. Most PR3+ cells lacked multilobate nuclei, distinguishing them from mature neutrophils, suggesting that these cells may be overlooked by conventional light microscopy. Conclusions PR3+ myeloid cells are a prominent and heterogeneous population in lupus nephritis. While intraglomerular PR3+ cells were specific to proliferative LN and correlated with histologic activity, the widespread presence of PR3+ cells in the tubulointerstitium suggests broader involvement in renal inflammation than previously recognized. These findings reveal a potentially overlooked immune cell population that may contribute to renal injury in LN.
Reference Key
openalex_W7169510242 Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Alessandra Ida Celia, C Lee, X. J. Yang, T Li, Kelly Casella, Angelique Cortez, Cristiano Alessandri, Fabrizio Conti, Eugene Shenderov, Michelle Petri, Sladjana Skopelja‐Gardner, Avi Rosenberg, Andrea Fava
Journal Lara D. Veeken
Year 2026
DOI
10.1093/rheumatology/keag374
URL
https://doi.org/10.1093/rheumatology/keag374
Keywords Keywords not found

Citations

No citations found. To add a citation, contact the admin at info@scimatic.org

Comments

No comments yet. Be the first to comment on this article.