Beyond Aging, Sex and Insomnia Disorder Shape NREM Brain Oscillations

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ID: 321139
2026
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Abstract
STUDY OBJECTIVES: Chronic insomnia disorder (INS) is particularly prevalent in older adults and females. Sex- and age-related differences in neurophysiological markers of sleep quality (sleep spindles and slow-wave activity [SWA]) may underlie differential vulnerability to INS. This study investigated the effects of sex and chronic insomnia disorder on spindle and SWA beyond aging, to better understand the mechanistic differences contributing to the higher prevalence of INS in females. METHODS: After a habituation night, one night of sleep assessed with polysomnography was analyzed in 222 adults (aged 18-82) including 119 INS (71% female) and 103 healthy sleepers (HS; 61% female). Spindle density, slow oscillation (SO) density, relative sigma power and SWA were derived during NREM sleep. Age, group, sex, and group-by-sex interactions were examined, with age as a covariate. RESULTS: Age, INS, and sex each contributed uniquely to NREM oscillatory activity. INS primarily reduced spindle and SO density, while sex accounted for differences in SWA. While SWA was higher in females overall, sex differences were not significant within the INS or HS groups. Female INS reported highest rates of insomnia severity as well as lower sigma power than males in the INS group. Spindle and SO density deficits were also present in female INS relative to female HS, as well as male INS relative to male HS. CONCLUSIONS: The combination of reduced sigma power in females with chronic insomnia disorder relative to their male counterparts, as well as less spindle and SO density compared to female healthy sleepers may contribute to greater insomnia severity in females.
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Authors Nyissa A Walsh, Aurore A Perrault, Nathan E Cross, Antonia Maltezos, Emma-Maria Phillips, Loïc Barbaux, Oren Weiner, Claire Dyment, Florence Borgetto, Jean-Phillipe Gouin, Thien Thanh Dang-Vu
Journal Sleep & breathing = Schlaf & Atmung
Year 2026
DOI
10.1093/sleep/zsag192
URL
https://doi.org/10.1093/sleep/zsag192
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