The MYB transcription factor APL is a rational target for base editing to engineer flowering time

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ID: 321062
2026
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Abstract
Abstract Achieving optimal flowering time is a pivotal factor in precision plant breeding. Here, in maize, we characterized an EMS-induced additive delayed-flowering mutant, edf1. edf1 and its heterozygotes are late-flowering under both long- and short-day photoperiods in the field, and harbor a splice-donor mutation in ALTERED PHLOEM DEVELOPMENT (APL). This mutation leads to the accumulation of the minor APL-β transcript, a splice variant expressed across a large natural maize population. Expression of the major splice variant APL-α is associated with flowering initiation; APL knock-down delays flowering and results in taller plants with increased biomass and plot yield. APL-α binds to and activates the promoter of ZCN8 to trigger flowering, while APL-β has impaired DNA-binding activity and antagonizes APL-α function. Base editing of the APL MYB domain in an elite rice cultivar and Arabidopsis results in delayed flowering, providing a feasible approach to regulate flowering time for the molecular breeding of staple crops.
Reference Key
openalex_W7168410679 Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Zhiwei Zhao, Huafeng Liang, Chengxiu Wu, Yifan Ni, Fei Wang, Fan Feng, Xin Zhang, Jingzhen Liu, Juan Yi, Xuan Du, Chunyi Zhang, Xiaoduo Lu, Yingjie Xiao, Jianbing Yan, Hongtao Liu
Journal The Plant cell
Year 2026
DOI
10.1093/plcell/koag215
URL
https://doi.org/10.1093/plcell/koag215
Keywords Keywords not found

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